P-613 Deletion of the CLPP gene in oocytes exacerbates chemotherapy-induced ovarian damage
Gu J, Guo C, Xiao Y, Hua R, Hai Z, Zhao P, Su J, Wang T. P-613 Deletion of the CLPP gene in oocytes exacerbates chemotherapy-induced ovarian damage. Human Reproduction 2023, 38 DOI: 10.1093/humrep/dead093.942.Peer-Reviewed Original ResearchChemotherapy-induced ovarian damageOvarian damageOocyte functionOocyte competenceChemotherapeutic drugsPremature ovarian insufficiencyChemotherapeutic drug cyclophosphamideOocyte-specific deletionTest of miceCaseinolytic peptidase PEarly embryo developmentClpP geneCyclophosphamide modelAneuploidy rateMII oocytesProportion of folliclesMII stageOvarian insufficiencyCKO miceWider implicationsChemotherapy drugsMouse modelMitochondrial distributionDrug cyclophosphamideOocyte maturationMitochondrial stress response gene Clpp deficiency impairs oocyte competence and deteriorate cyclophosphamide-induced ovarian damage in young mice
Li G, Gu J, Zhou X, Wu T, Li X, Hua R, Hai Z, Xiao Y, Su J, Yeung W, Liu K, Guo C, Wang T. Mitochondrial stress response gene Clpp deficiency impairs oocyte competence and deteriorate cyclophosphamide-induced ovarian damage in young mice. Frontiers In Endocrinology 2023, 14: 1122012. PMID: 37033217, PMCID: PMC10081448, DOI: 10.3389/fendo.2023.1122012.Peer-Reviewed Original ResearchConceptsCyclophosphamide-induced ovarian damageOvarian damageOocyte-specific deletionOocyte competencePremature ovarian insufficiencyImpaired oocyte competenceChemotherapeutic drug cyclophosphamideCaseinolytic peptidase PDecreased mitochondrial membrane potentialAneuploidy rateMII oocytesCTX treatmentElevated ROS levelsOvarian insufficiencyEarly folliculogenesisKnockout miceYoung miceMitochondrial membrane potentialMouse modelDrug cyclophosphamideTreat cancerMiceOocytesSpindle rateMembrane potential
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