2002
Genetic and Immunohistochemical Analysis of Pancreatic Acinar Cell Carcinoma Frequent Allelic Loss on Chromosome 11p and Alterations in the APC/β-Catenin Pathway
Abraham S, Wu T, Hruban R, Lee J, Yeo C, Conlon K, Brennan M, Cameron J, Klimstra D. Genetic and Immunohistochemical Analysis of Pancreatic Acinar Cell Carcinoma Frequent Allelic Loss on Chromosome 11p and Alterations in the APC/β-Catenin Pathway. American Journal Of Pathology 2002, 160: 953-962. PMID: 11891193, PMCID: PMC1867188, DOI: 10.1016/s0002-9440(10)64917-6.Peer-Reviewed Original ResearchMeSH KeywordsAdenomatous Polyposis Coli ProteinAdolescentAdultAgedbeta CateninCarcinoma, Acinar CellChild, PreschoolChromosomes, Human, Pair 11Chromosomes, Human, Pair 5Cytoskeletal ProteinsFemaleGenes, Tumor SuppressorHumansImmunohistochemistryLoss of HeterozygosityMaleMiddle AgedMutationPancreatic NeoplasmsSignal TransductionTrans-ActivatorsConceptsAllelic lossChromosome 11pAcinar cell carcinomaAPC/beta-catenin pathwayAllelic shiftsAPC/beta-cateninFrequency of allelic lossChromosome arm 11pPancreatic ductal adenocarcinomaFrequent allelic lossDpc4 protein expressionBeta-catenin oncogeneMicrosatellite markersDuctal adenocarcinomaPolymerase chain amplificationMolecular alterationsMicrosatellite instabilityTruncating APC mutationsSomatic alterationsChromosomeRare pancreatic neoplasmP53 accumulationGenetic alterationsBeta-CateninMicrosatellite
2001
Distinctive Molecular Genetic Alterations in Sporadic and Familial Adenomatous Polyposis-Associated Pancreatoblastomas Frequent Alterations in the APC/β-Catenin Pathway and Chromosome 11p
Abraham S, Wu T, Klimstra D, Finn L, Lee J, Yeo C, Cameron J, Hruban R. Distinctive Molecular Genetic Alterations in Sporadic and Familial Adenomatous Polyposis-Associated Pancreatoblastomas Frequent Alterations in the APC/β-Catenin Pathway and Chromosome 11p. American Journal Of Pathology 2001, 159: 1619-1627. PMID: 11696422, PMCID: PMC1867075, DOI: 10.1016/s0002-9440(10)63008-8.Peer-Reviewed Original ResearchMeSH KeywordsAdenomatous Polyposis ColiAdenomatous Polyposis Coli ProteinAllelesBase Sequencebeta CateninChildChild, PreschoolChromosomes, Human, Pair 11Cytoskeletal ProteinsDNA-Binding ProteinsFemaleGenes, p53Genes, rasHumansLoss of HeterozygosityMaleMiddle AgedMolecular BiologyMutationNeoplasms, Germ Cell and EmbryonalPancreatic NeoplasmsSmad4 ProteinTrans-ActivatorsConceptsChromosome 11pDNA sequencesPancreatic ductal adenocarcinomaDPC4 tumor suppressor genesGenetic alterationsBeta-CateninFamilial adenomatous polyposisK-rasAllelic loss assaysAccumulation of beta-catenin proteinDpc4 protein expressionDuctal adenocarcinomaAdenomatous polyposis coli (APC)/beta-catenin pathwaySequencing of exon 3DNA sequencing of exon 3Tumor suppressor geneBeta-catenin oncogeneBeta-catenin proteinAbnormal nuclear accumulationMolecular genetic alterationsMutation cluster regionNuclear accumulation of beta-catenin proteinExon 1 of K-rasBeta-catenin geneAllelic loss
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