Solid-Pseudopapillary Tumors of the Pancreas Are Genetically Distinct from Pancreatic Ductal Adenocarcinomas and Almost Always Harbor β-catenin Mutations
Abraham S, Klimstra D, Wilentz R, Yeo C, Conlon K, Brennan M, Cameron J, Wu T, Hruban R. Solid-Pseudopapillary Tumors of the Pancreas Are Genetically Distinct from Pancreatic Ductal Adenocarcinomas and Almost Always Harbor β-catenin Mutations. American Journal Of Pathology 2002, 160: 1361-1369. PMID: 11943721, PMCID: PMC1867216, DOI: 10.1016/s0002-9440(10)62563-1.Peer-Reviewed Original ResearchConceptsSolid pseudopapillary tumorDNA sequencesAPC/beta-catenin pathwayAPC/beta-cateninDPC4 tumor suppressor genesPancreatic ductal adenocarcinomaK-rasDuctal adenocarcinomaAccumulation of beta-catenin proteinCyclin D1Beta-catenin exon 3Cell cycle proteinsTumor suppressor genePathways of neoplastic progressionPancreatic neoplasmsBeta-catenin proteinNuclear accumulation of beta-catenin proteinNeoplasm of low malignant potentialBeta-catenin dysregulationMutation cluster regionGenetic pathwaysLow malignant potentialImmunohistochemical labelingBeta-catenin mutationsAcinar cell carcinomaGenetic and Immunohistochemical Analysis of Pancreatic Acinar Cell Carcinoma Frequent Allelic Loss on Chromosome 11p and Alterations in the APC/β-Catenin Pathway
Abraham S, Wu T, Hruban R, Lee J, Yeo C, Conlon K, Brennan M, Cameron J, Klimstra D. Genetic and Immunohistochemical Analysis of Pancreatic Acinar Cell Carcinoma Frequent Allelic Loss on Chromosome 11p and Alterations in the APC/β-Catenin Pathway. American Journal Of Pathology 2002, 160: 953-962. PMID: 11891193, PMCID: PMC1867188, DOI: 10.1016/s0002-9440(10)64917-6.Peer-Reviewed Original ResearchMeSH KeywordsAdenomatous Polyposis Coli ProteinAdolescentAdultAgedbeta CateninCarcinoma, Acinar CellChild, PreschoolChromosomes, Human, Pair 11Chromosomes, Human, Pair 5Cytoskeletal ProteinsFemaleGenes, Tumor SuppressorHumansImmunohistochemistryLoss of HeterozygosityMaleMiddle AgedMutationPancreatic NeoplasmsSignal TransductionTrans-ActivatorsConceptsAllelic lossChromosome 11pAcinar cell carcinomaAPC/beta-catenin pathwayAllelic shiftsAPC/beta-cateninFrequency of allelic lossChromosome arm 11pPancreatic ductal adenocarcinomaFrequent allelic lossDpc4 protein expressionBeta-catenin oncogeneMicrosatellite markersDuctal adenocarcinomaPolymerase chain amplificationMolecular alterationsMicrosatellite instabilityTruncating APC mutationsSomatic alterationsChromosomeRare pancreatic neoplasmP53 accumulationGenetic alterationsBeta-CateninMicrosatellite
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