Distinctive Molecular Genetic Alterations in Sporadic and Familial Adenomatous Polyposis-Associated Pancreatoblastomas Frequent Alterations in the APC/β-Catenin Pathway and Chromosome 11p
Abraham S, Wu T, Klimstra D, Finn L, Lee J, Yeo C, Cameron J, Hruban R. Distinctive Molecular Genetic Alterations in Sporadic and Familial Adenomatous Polyposis-Associated Pancreatoblastomas Frequent Alterations in the APC/β-Catenin Pathway and Chromosome 11p. American Journal Of Pathology 2001, 159: 1619-1627. PMID: 11696422, PMCID: PMC1867075, DOI: 10.1016/s0002-9440(10)63008-8.Peer-Reviewed Original ResearchMeSH KeywordsAdenomatous Polyposis ColiAdenomatous Polyposis Coli ProteinAllelesBase Sequencebeta CateninChildChild, PreschoolChromosomes, Human, Pair 11Cytoskeletal ProteinsDNA-Binding ProteinsFemaleGenes, p53Genes, rasHumansLoss of HeterozygosityMaleMiddle AgedMolecular BiologyMutationNeoplasms, Germ Cell and EmbryonalPancreatic NeoplasmsSmad4 ProteinTrans-ActivatorsConceptsChromosome 11pDNA sequencesPancreatic ductal adenocarcinomaDPC4 tumor suppressor genesGenetic alterationsBeta-CateninFamilial adenomatous polyposisK-rasAllelic loss assaysAccumulation of beta-catenin proteinDpc4 protein expressionDuctal adenocarcinomaAdenomatous polyposis coli (APC)/beta-catenin pathwaySequencing of exon 3DNA sequencing of exon 3Tumor suppressor geneBeta-catenin oncogeneBeta-catenin proteinAbnormal nuclear accumulationMolecular genetic alterationsMutation cluster regionNuclear accumulation of beta-catenin proteinExon 1 of K-rasBeta-catenin geneAllelic loss
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