2016
Relation Between Platelet Count and Platelet Reactivity to Thrombotic and Bleeding Risk: From the Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents Study
Giustino G, Kirtane AJ, Généreux P, Baber U, Witzenbichler B, Neumann FJ, Weisz G, Maehara A, Rinaldi MJ, Metzger C, Henry TD, Cox DA, Duffy PL, Mazzaferri EL, Brodie BR, Stuckey TD, Dangas GD, Francese DP, Litherland C, Mehran R, Stone GW. Relation Between Platelet Count and Platelet Reactivity to Thrombotic and Bleeding Risk: From the Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents Study. The American Journal Of Cardiology 2016, 117: 1703-1713. PMID: 27067621, DOI: 10.1016/j.amjcard.2016.03.001.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlood PlateletsCause of DeathCoronary ThrombosisDose-Response Relationship, DrugDrug Therapy, CombinationDrug-Eluting StentsFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsPlatelet CountPostoperative HemorrhageProspective StudiesRisk FactorsSurvival RateTreatment OutcomeUnited StatesConceptsDrug-Eluting Stents studyDual antiplatelet therapyPlatelet countHigher platelet countsDrug-eluting stentsPlatelet reactivityAntiplatelet therapyMultivariable adjustmentThrombotic complicationsStent studiesHigh riskCoronary artery implantationResidual platelet reactivitySimple hematological parametersSpontaneous myocardial infarctionLow platelet countBleeding riskCause mortalityDES implantationCrude riskPlatelet inhibitionHemorrhagic riskRisk stratificationStudy cohortThrombotic events
2015
Incidence, Predictors, and Impact of Post-Discharge Bleeding After Percutaneous Coronary Intervention
Généreux P, Giustino G, Witzenbichler B, Weisz G, Stuckey TD, Rinaldi MJ, Neumann FJ, Metzger DC, Henry TD, Cox DA, Duffy PL, Mazzaferri E, Yadav M, Francese DP, Palmerini T, Kirtane AJ, Litherland C, Mehran R, Stone GW. Incidence, Predictors, and Impact of Post-Discharge Bleeding After Percutaneous Coronary Intervention. Journal Of The American College Of Cardiology 2015, 66: 1036-1045. PMID: 26314532, DOI: 10.1016/j.jacc.2015.06.1323.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCoronary Artery DiseaseDose-Response Relationship, DrugDrug Administration ScheduleDrug-Eluting StentsFollow-Up StudiesHumansMiddle AgedMultivariate AnalysisPatient DischargePercutaneous Coronary InterventionPlatelet AggregationPlatelet Aggregation InhibitorsPostoperative CarePostoperative HemorrhagePredictive Value of TestsProportional Hazards ModelsProspective StudiesRadiographyRisk AssessmentSurvival AnalysisTreatment OutcomeConceptsPost-discharge bleedingPost-discharge myocardial infarctionPercutaneous coronary interventionSuccessful percutaneous coronary interventionADAPT-DES studyCause mortalityCoronary interventionChronic oral anticoagulation therapyDrug-eluting stent implantationCox proportional hazards regressionLower baseline hemoglobinSuccessful DES implantationUnrestricted patient populationOral anticoagulation therapyLow platelet reactivityProportional hazards regressionHigher crude ratesBaseline hemoglobinHospital survivorsAnticoagulation therapyGastrointestinal bleedingDES implantationHospital dischargeMultivariable adjustmentPrognostic impact
2012
DOES PLATELET FUNCTION TESTING ADD SIGNIFICANT INCREMENTAL RISK STRATIFICATION TO UNSELECTED PATIENTS UNDERGOING DES IMPLANTATION? THE ADAPT-DES STUDY
Kirtane A, Parise H, Witzenbichler B, Weisz G, Rinaldi M, Neumann F, Metzger D, Henry T, Cox D, Duffy P, Brodie B, Stuckey T, Mazzaferri E, Cristea E, Mehran R, Stone G. DOES PLATELET FUNCTION TESTING ADD SIGNIFICANT INCREMENTAL RISK STRATIFICATION TO UNSELECTED PATIENTS UNDERGOING DES IMPLANTATION? THE ADAPT-DES STUDY. Journal Of The American College Of Cardiology 2012, 59: e292. DOI: 10.1016/s0735-1097(12)60293-9.Peer-Reviewed Original Research
2010
Serial angiographic and intravascular ultrasound evaluation to interrogate the presence of late “catch-up” phenomenon after cypher® sirolimus-eluting stent implantation
Chamié D, Abizaid A, Costa J, Feres F, Almiro da Silva J, Mattos L, Staico R, Costa R, Abizaid A, Tanajura L, Sousa A, Sousa J. Serial angiographic and intravascular ultrasound evaluation to interrogate the presence of late “catch-up” phenomenon after cypher® sirolimus-eluting stent implantation. The International Journal Of Cardiovascular Imaging 2010, 27: 867-874. PMID: 21082255, DOI: 10.1007/s10554-010-9723-z.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnalysis of VarianceAngioplasty, Balloon, CoronaryBrazilCardiovascular AgentsChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary RestenosisDrug-Eluting StentsFemaleHumansHyperplasiaMaleMiddle AgedPredictive Value of TestsProsthesis DesignRisk AssessmentRisk FactorsSirolimusTime FactorsTomography, X-Ray ComputedTreatment OutcomeUltrasonography, InterventionalConceptsSirolimus-eluting stent implantationSirolimus-eluting stentsIn-stent late lossLate lossIntravascular ultrasoundBaseline reference vessel diameterLeft anterior descending arteryAnterior descending arteryInvasive follow-upIntimal hyperplasiaFrequent target vesselReference vessel diameterIntravascular ultrasound analysisIntravascular ultrasound evaluationNon-complex patientsPrimary endpointUltrasound evaluationNon-significant increaseDescending arteryFollow-upStent implantationDES implantationIn-stentIH volumeSerial angiography
2009
Intravascular Ultrasound Assessment of the Incidence and Predictors of Edge Dissections After Drug-Eluting Stent Implantation
Liu X, Tsujita K, Maehara A, Mintz GS, Weisz G, Dangas GD, Lansky AJ, Kreps EM, Rabbani LE, Collins M, Stone GW, Moses JW, Mehran R, Leon MB. Intravascular Ultrasound Assessment of the Incidence and Predictors of Edge Dissections After Drug-Eluting Stent Implantation. JACC Cardiovascular Interventions 2009, 2: 997-1004. PMID: 19850262, DOI: 10.1016/j.jcin.2009.07.012.Peer-Reviewed Original ResearchConceptsStent edge dissectionEdge dissectionDES implantationPlaque eccentricityIntravascular ultrasoundIntramural hematomaPlaque burdenStent implantationStent edgeDrug-eluting stent implantationDistal stent edgeStent restenosis lesionsBare-metal stentingIntravascular ultrasound assessmentResidual plaque areaCoronary dissectionRestenosis lesionsAngiographic findingsIndependent predictorsHematoma groupResidual plaqueUltrasound assessmentDissection groupPlaque areaNondissection group
2008
Angiographic Patterns of Drug-Eluting Stent Restenosis and One-Year Outcomes After Treatment With Repeated Percutaneous Coronary Intervention
Solinas E, Dangas G, Kirtane AJ, Lansky AJ, Franklin-Bond T, Boland P, Syros G, Kim YH, Gupta A, Mintz G, Fahy M, Collins M, Kodali S, Stone GW, Moses JW, Leon MB, Mehran R. Angiographic Patterns of Drug-Eluting Stent Restenosis and One-Year Outcomes After Treatment With Repeated Percutaneous Coronary Intervention. The American Journal Of Cardiology 2008, 102: 311-315. PMID: 18638592, DOI: 10.1016/j.amjcard.2008.03.060.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionMajor adverse cardiac eventsPatterns of ISRAdverse cardiac eventsTarget lesion revascularizationDES-ISRCoronary interventionPES-ISRCardiac eventsBalloon angioplastyStent restenosisDrug-eluting stent implantationColumbia University Medical CenterDES-ISR lesionsOne-year outcomesPaclitaxel-eluting stentsUnselected patient populationSirolimus-eluting stentsUniversity Medical CenterLow overall rateAngiographic patternsDES implantationDES placementISR lesionsConsecutive patients
2007
Clinical Outcomes After Heterogeneous Overlap Stenting With Drug-Eluting Stents and Bare-Metal Stents for de Novo Coronary Artery Narrowings
Aoki J, Kirtane AJ, Dangas GD, Lansky AJ, Morales A, Kimura M, Kim YH, Moussa I, Weisz G, Kreps EM, Collins M, Frankin-Bond T, Stone GW, Moses JW, Leon MB, Mehran R. Clinical Outcomes After Heterogeneous Overlap Stenting With Drug-Eluting Stents and Bare-Metal Stents for de Novo Coronary Artery Narrowings. The American Journal Of Cardiology 2007, 101: 58-62. PMID: 18157966, DOI: 10.1016/j.amjcard.2007.07.049.Peer-Reviewed Original ResearchConceptsDrug-eluting stentsBare metal stentsClinical outcomesTarget vessel revascularization rateMultiple drug-eluting stentsAcute stent thrombosisVessel revascularization rateDe novo lesionsTarget vessel revascularizationPercutaneous coronary interventionCoronary artery narrowingImplanted stent diameterNovo lesionsProspective registryRevascularization ratesVessel revascularizationBMS implantationCoronary interventionDES implantationConsecutive patientsArtery narrowingStent thrombosisMyocardial infarctionStent restenosisStent diameter
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