2005
The Division of Drosophila Germline Stem Cells and Their Precursors Requires a Specific Cyclin
Wang Z, Lin H. The Division of Drosophila Germline Stem Cells and Their Precursors Requires a Specific Cyclin. Current Biology 2005, 15: 328-333. PMID: 15723793, DOI: 10.1016/j.cub.2005.02.016.Peer-Reviewed Original ResearchConceptsPrimordial germ cellsGSC divisionG2 cyclinsDrosophila germline stem cellsCyclin BGermline stem cellsCell-autonomous functionSpecific cell cycle regulatorsStem cell biologyStem cell cycleStem cellsCell cycle regulatorsSomatic lineagesFemale GSCsMutant defectsB cyclinsRedundant rolesSpecific cyclinsCell biologyDistinct functionsCycle regulatorsCell cycleGerm cellsCycBCyclin A
2003
Mitotic Regulation of Ribosomal S6 Kinase 1 Involves Ser/Thr, Pro Phosphorylation of Consensus and Non-consensus Sites by Cdc2*
Shah OJ, Ghosh S, Hunter T. Mitotic Regulation of Ribosomal S6 Kinase 1 Involves Ser/Thr, Pro Phosphorylation of Consensus and Non-consensus Sites by Cdc2*. Journal Of Biological Chemistry 2003, 278: 16433-16442. PMID: 12586835, DOI: 10.1074/jbc.m300435200.Peer-Reviewed Original ResearchConceptsSer/ThrMultiple Ser/ThrRibosomal S6 kinase 1Hydrophobic motif siteRibosomal protein mRNAsRNA polymerase IIProline-directed phosphorylationRibosomal protein synthesisPhosphorylation of S6K1S6 kinase 1Mitotic HeLa cellsCyclin-dependent kinasesActivity of cdc2Elongation factor 1gammaNon-consensus sitesRibosome biogenesisMitotic regulationPolymerase IIPhosphorylation sitesMRNA processingMotif sitesProtein kinaseTriggers inactivationMitotic processesCyclin B
2002
Control of DNA Replication and Chromosome Ploidy by Geminin and Cyclin A
Mihaylov IS, Kondo T, Jones L, Ryzhikov S, Tanaka J, Zheng J, Higa LA, Minamino N, Cooley L, Zhang H. Control of DNA Replication and Chromosome Ploidy by Geminin and Cyclin A. Molecular And Cellular Biology 2002, 22: 1868-1880. PMID: 11865064, PMCID: PMC135598, DOI: 10.1128/mcb.22.6.1868-1880.2002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Cycle ProteinsCell LineCell NucleusCheckpoint Kinase 1ChromosomesCyclin ACyclin BDNADNA ReplicationDNA-Binding ProteinsDown-RegulationDrosophilaDrosophila ProteinsFlow CytometryGene SilencingMolecular Sequence DataPloidiesProtein Kinase InhibitorsProtein KinasesRNA, Double-StrandedSequence Homology, Amino AcidConceptsDNA replicationGeminin deficiencyGenome stabilityCyclin ASingle giant nucleusGiant nucleiCell cycle arrestDrosophila homologueDrosophila cellsGenome instabilityCheckpoint controlChromosome ploidyReplication factorsOverreplicationCyclin BGemininDouble knockoutCycle arrestRapid downregulationDNA contentGenomeSilencingEffect of cyclinHomologuesCyclin
1993
Phosphorylation independent activation of human cyclin-dependent kinase 2 by cyclin A in vitro.
Connell-Crowley L, Solomon M, Wei N, Harper J. Phosphorylation independent activation of human cyclin-dependent kinase 2 by cyclin A in vitro. Molecular Biology Of The Cell 1993, 4: 79-92. PMID: 8443411, PMCID: PMC300902, DOI: 10.1091/mbc.4.1.79.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceCDC2-CDC28 KinasesCyclin-Dependent Kinase 2Cyclin-Dependent KinasesCyclinsDNAEnzyme ActivationHumansIn Vitro TechniquesMolecular Sequence DataMutagenesis, Site-DirectedPhosphorylationProtein KinasesProtein Serine-Threonine KinasesSaccharomyces cerevisiaeXenopusXenopus ProteinsConceptsCDK2/cyclinCyclin-dependent kinase 2Cyclin AKinase 2Cyclin BPhosphorylation-independent activationSerine-threonine proteinCdc2/cyclin BCDK2/cyclin AHuman cyclin-dependent kinase 2G1/S transitionHistone H1 kinaseCyclin B complexCell cycle progressionSpecific activityCyclin bindingRecombinant CDK2Mammalian cellsH1 kinaseBacterial expressionT160 phosphorylationCycle progressionXenopus eggsCell extractsCyclin
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