2000
Synthesis and evaluation of an 18F analog of forskolin for imaging adenylyl cyclase
Kiesewetter D, Sassaman M, Robbins J, Jagoda E, Carson R, Appel N, Sutkowski E, Herscovitch P, Braun A, Eckelman W. Synthesis and evaluation of an 18F analog of forskolin for imaging adenylyl cyclase. Journal Of Fluorine Chemistry 2000, 101: 297-304. DOI: 10.1016/s0022-1139(99)00174-8.Peer-Reviewed Original ResearchEffective imaging agentRapid deprotectionCarbamate analoguesAdenylyl cyclaseImaging agentPositron emission tomographyBrain uptakeSecond messenger systemsEmission tomographyDeprotectionLiving brainAnaloguesAminesAnalogue of forskolinFluorineMessenger systemsForskolinSynthesisCompoundsPotential agentCarbamateCyclase
1990
Stimulation of adenylate cyclase activity in cultured endothelial cells subjected to cyclic stretch.
Letsou GV, Rosales O, Maitz S, Vogt A, Sumpio BE. Stimulation of adenylate cyclase activity in cultured endothelial cells subjected to cyclic stretch. The Journal Of Cardiovascular Surgery 1990, 31: 634-9. PMID: 2229164.Peer-Reviewed Original ResearchConceptsEndothelial cellsAdenylate cyclaseAdenylate cyclase activityEndothelial cell functionVascular endothelial cellsAortic endothelial cellsCultured endothelial cellsMembrane adenylate cyclaseTime-dependent increaseBovine aortic endothelial cellsHemodynamic changesCardiac outputRate of proliferationStretch receptorsCulture wellsPulsatile stretchingStatic culture techniquesPulsatile stressCrude membrane preparationsCyclase activityCell functionVascular biologySecretion of macromoleculesCyclasePulsatile nature
1988
Synthetic human parathyroid hormone-like protein stimulates bone resorption and causes hypercalcemia in rats.
Stewart AF, Mangin M, Wu T, Goumas D, Insogna KL, Burtis WJ, Broadus AE. Synthetic human parathyroid hormone-like protein stimulates bone resorption and causes hypercalcemia in rats. Journal Of Clinical Investigation 1988, 81: 596-600. PMID: 3339131, PMCID: PMC329608, DOI: 10.1172/jci113358.Peer-Reviewed Original ResearchConceptsBone-resorbing agentsMicrograms/hParathyroid hormone-like proteinFetal rat long bonesAdenylate cyclasePotent bone-resorbing agentHormone-like proteinRat long bonesMembrane adenylate cyclaseSerum calciumHumoral hypercalcemiaOsmotic minipumpsBone resorptionPotent agonistLong bonesSuch synthetic peptidesHypercalcemiaRatsDlVivo bioactivityCyclaseSynthetic peptidesAgentsMinipumpsPatients
1983
Protein Phosphorylation in Cultured Human Ciliary Epithelia in Response to Activators of Adenylate Cyclase, Cyclic AMP and Analogues
Coca-Prados M, Kondo K, Sears M. Protein Phosphorylation in Cultured Human Ciliary Epithelia in Response to Activators of Adenylate Cyclase, Cyclic AMP and Analogues. 1983, 1-6. DOI: 10.1007/978-3-642-69096-9_1.Peer-Reviewed Original ResearchSpecific substrate proteinsDiverse cell systemsProtein kinase activityState of phosphorylationCyclic AMPSubstrate proteinsProtein phosphorylationEndogenous proteinsKinase activitySecond messengerHuman ciliary epitheliumPhosphorylationMembrane permeabilityProteinCell systemAdenylate cyclaseCiliary epitheliumBiologic responseMessengerActivatorAMPCyclaseResponse
1979
Dopamine inhibits adenylate cyclase in human prolactin-secreting pituitary adenomas
DE CAMILLI P, MACCONI D, SPADA A. Dopamine inhibits adenylate cyclase in human prolactin-secreting pituitary adenomas. Nature 1979, 278: 252-254. PMID: 423973, DOI: 10.1038/278252a0.Peer-Reviewed Original ResearchConceptsDA receptorsPRL secretionProlactin-secreting pituitary adenomasAdenylate cyclaseBasal adenylate cyclaseSame pharmacological propertiesClasses of receptorsDopamine inhibitsDopaminergic agonistsProlactin secretionPituitary adenomasNormal anteriorPRL adenomasPharmacological propertiesReceptorsSecretionCyclic AMPAdenomasCyclaseAgonistsAnteriorPRL
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