Stereoselective Synthesis of Allenyl Alcohols by Cobalt(III)‐Catalyzed Sequential C−H Bond Addition to 1,3‐Enynes and Aldehydes
Xu C, Tassone J, Mercado B, Ellman J. Stereoselective Synthesis of Allenyl Alcohols by Cobalt(III)‐Catalyzed Sequential C−H Bond Addition to 1,3‐Enynes and Aldehydes. Angewandte Chemie 2022, 134 DOI: 10.1002/ange.202202364.Peer-Reviewed Original ResearchBond additionX-ray structural characterizationFirst exampleCoupling partnersSilyl groupStructural characterizationStereoselective synthesisBond substratesCyclization conditionsAdjacent alcoholsAllenyl alcoholsCo IIIEnynesLarge substituentsHigh stereoselectivityBrook rearrangementAlcohol productsAldehydesCatalyzed SequentialEffective substrateAlkynesAlcoholCobaltacycleSubstituentsAllenesStereoselective Synthesis of Allenyl Alcohols by Cobalt(III)‐Catalyzed Sequential C−H Bond Addition to 1,3‐Enynes and Aldehydes
Xu C, Tassone JP, Mercado BQ, Ellman JA. Stereoselective Synthesis of Allenyl Alcohols by Cobalt(III)‐Catalyzed Sequential C−H Bond Addition to 1,3‐Enynes and Aldehydes. Angewandte Chemie International Edition 2022, 61: e202202364. PMID: 35420724, PMCID: PMC9189073, DOI: 10.1002/anie.202202364.Peer-Reviewed Original ResearchConceptsH bond additionBond additionX-ray structural characterizationH bond substratesFirst exampleCoupling partnersSilyl groupStructural characterizationStereoselective synthesisBond substratesCyclization conditionsEnynesAdjacent alcoholsAllenyl alcoholsLarge substituentsHigh stereoselectivityBrook rearrangementAldehydesAlcohol productsCatalyzed SequentialEffective substrateAlkynesAlcoholCobaltacycleSubstituents
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