Inactivation of SPAK kinase reduces body weight gain in mice fed a high-fat diet by improving energy expenditure and insulin sensitivity
Torre-Villalvazo I, Cervantes-Pérez L, Noriega L, Jiménez J, Uribe N, Chávez-Canales M, Tovar-Palacio C, Marfil-Garza B, Torres N, Bobadilla N, Tovar A, Gamba G. Inactivation of SPAK kinase reduces body weight gain in mice fed a high-fat diet by improving energy expenditure and insulin sensitivity. AJP Endocrinology And Metabolism 2017, 314: e53-e65. PMID: 29066461, DOI: 10.1152/ajpendo.00108.2017.Peer-Reviewed Original ResearchConceptsSTE20/SPS1-related proline-alanine-rich protein kinaseInsulin sensitivityHigh-fat dietGlucose toleranceElectroneutral cation-chloride cotransportersEnergy expenditureResistant to HFD-induced obesityAssociated with decreased blood pressureTransepithelial salt transportRegulation of energy balanceCation-chloride cotransportersTreatment of obesityAdipose tissue hypertrophyReduced body weight gainWhole-body insulin sensitivityObesity susceptibility genesWhite adipose tissue hypertrophyWeight gainHFD-induced obesitySLC12 familySPAK kinaseMetabolic syndromeTissue hypertrophyEvaluate weight gainBlood pressure
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