2018
Immediate Postablation 18F-FDG Injection and Corresponding SUV Are Surrogate Biomarkers of Local Tumor Progression After Thermal Ablation of Colorectal Carcinoma Liver Metastases
Cornelis F, Petre E, Vakiani E, Klimstra D, Durack J, Gonen M, Osborne J, Solomon S, Sofocleous C. Immediate Postablation 18F-FDG Injection and Corresponding SUV Are Surrogate Biomarkers of Local Tumor Progression After Thermal Ablation of Colorectal Carcinoma Liver Metastases. Journal Of Nuclear Medicine 2018, 59: 1360-1365. PMID: 29439012, PMCID: PMC6126442, DOI: 10.2967/jnumed.117.194506.Peer-Reviewed Original ResearchConceptsLocal tumor progressionContrast-enhanced CT imagesSUV ratioTumor progressionPostablation biopsiesLiver metastasesTumor cellsAblation of colorectal liver metastasesPredictor of local tumor progressionInstitutional review board-approved prospective studyLocal tumor progression rateMargin sizeMedian follow-up periodColorectal carcinoma liver metastasesCompeting-risks regression modelsTumor-negative biopsiesCT imagesF-FDG PET/CTTumor progression rateColorectal liver metastasesCompeting-risk analysisFollow-up periodTumor-positive biopsiesSurrounding normal liverSubdistribution hazard ratios
2014
Histological features and severity of oxaliplatin‐induced liver injury and clinical associations
Nalbantoglu I, Tan B, Linehan D, Gao F, Brunt E. Histological features and severity of oxaliplatin‐induced liver injury and clinical associations. Journal Of Digestive Diseases 2014, 15: 553-560. PMID: 25060628, DOI: 10.1111/1751-2980.12177.Peer-Reviewed Original ResearchConceptsOxaliplatin-induced liver injuryHigher injury scoresInjury scoreLiver injuryAspartate aminotransferaseElevated preoperative aspartate aminotransferaseShort-term postoperative complicationsSerum liver enzyme levelsColorectal carcinoma liver metastasesAbnormal AST levelsComponent of chemotherapyHepatic sinusoidal injuryPreoperative aspartate aminotransferaseMetastatic colorectal carcinomaLiver enzyme levelsLiver injury scoreBody mass indexLong-term outcomesSinusoidal lining cellsManifestations of injuryLight microscopic lesionsAlkaline phosphatase levelsInjury scoring systemNon-tumor liverLower injury scores
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