2020
Origin and Function of Stress-Induced IL-6 in Murine Models
Qing H, Desrouleaux R, Israni-Winger K, Mineur YS, Fogelman N, Zhang C, Rashed S, Palm NW, Sinha R, Picciotto MR, Perry RJ, Wang A. Origin and Function of Stress-Induced IL-6 in Murine Models. Cell 2020, 182: 372-387.e14. PMID: 32610084, PMCID: PMC7384974, DOI: 10.1016/j.cell.2020.05.054.Peer-Reviewed Original ResearchMeSH KeywordsAdipose Tissue, BrownAnimalsBone Marrow CellsBone Marrow TransplantationBrainChemokinesCytokinesDisease Models, AnimalGluconeogenesisHyperglycemiaInterleukin-6LiverMaleMiceMice, Inbred C57BLMice, KnockoutReceptors, Adrenergic, beta-3Receptors, Interleukin-6Stress, PsychologicalUncoupling Protein 1ConceptsInterleukin-6Subsequent inflammatory challengeAcute psychological stressBrown adipose tissueDominant cytokineImmunometabolic reprogrammingInflammatory challengeEndocrine organMurine modelMouse modelAdipose tissueNeuropsychiatric diseasesAcute stressHepatic gluconeogenesisStress hormonesBrown adipocytesPsychological stressDependent fashionDiseaseInstructive signalsHyperglycemiaInflammationCytokinesMortalityHormone
2019
Posttraumatic Stress Disorder and Risk for Early Incident Atrial Fibrillation: A Prospective Cohort Study of 1.1 Million Young Adults
Rosman L, Lampert R, Ramsey CM, Dziura J, Chui PW, Brandt C, Haskell S, Burg MM. Posttraumatic Stress Disorder and Risk for Early Incident Atrial Fibrillation: A Prospective Cohort Study of 1.1 Million Young Adults. Journal Of The American Heart Association 2019, 8: e013741. PMID: 31564191, PMCID: PMC6806049, DOI: 10.1161/jaha.119.013741.Peer-Reviewed Original ResearchConceptsIncident atrial fibrillationPosttraumatic stress disorderMiddle-aged veteransAtrial fibrillationRisk factorsMultivariate Cox proportional hazards modelIncidence of AFCox proportional hazards modelStress disorderAF risk factorsCardiovascular risk factorsNew atrial fibrillationProspective cohort studyHigher overall incidenceVeterans Health AdministrationProportional hazards modelAcute psychological stressChronic stress syndromeCohort studyOverall incidenceAtrial tachycardiaLifestyle factorsAtrial flutterHealthcare useEffect modification
2014
Stress‐Related Alcohol Consumption in Heavy Drinkers Correlates with Expression of miR‐10a, miR‐21, and Components of the TAR‐RNA‐Binding Protein‐Associated Complex
Beech RD, Leffert JJ, Lin A, Hong KA, Hansen J, Umlauf S, Mane S, Zhao H, Sinha R. Stress‐Related Alcohol Consumption in Heavy Drinkers Correlates with Expression of miR‐10a, miR‐21, and Components of the TAR‐RNA‐Binding Protein‐Associated Complex. Alcohol Clinical And Experimental Research 2014, 38: 2743-2753. PMID: 25421511, PMCID: PMC4244644, DOI: 10.1111/acer.12549.Peer-Reviewed Original ResearchConceptsMiR-21Psychological stressMD subjectsAcute psychological stressReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionGene expressionAlcohol intakeHD groupPeripheral bloodStress-related drinkingPolymerase chain reactionStimulus presentationModerate drinkersMD groupAlcohol-related cuesDrinking subjectsStress-induced drinkingAlcohol consumptionHeavy drinkersAlcohol dependenceAmount of beerMicroRNA-10aChain reactionMicroRNA-21Confluence of Depression and Acute Psychological Stress Among Patients With Stable Coronary Heart Disease: Effects on Myocardial Perfusion
Burg MM, Meadows J, Shimbo D, Davidson KW, Schwartz JE, Soufer R. Confluence of Depression and Acute Psychological Stress Among Patients With Stable Coronary Heart Disease: Effects on Myocardial Perfusion. Journal Of The American Heart Association 2014, 3: e000898. PMID: 25359402, PMCID: PMC4338683, DOI: 10.1161/jaha.114.000898.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedChi-Square DistributionChronic DiseaseConnecticutCoronary CirculationCoronary DiseaseDepressionFemaleHemodynamicsHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial Perfusion ImagingOdds RatioPredictive Value of TestsPsychiatric Status Rating ScalesRecurrenceRisk FactorsSeverity of Illness IndexStress, PsychologicalTomography, Emission-Computed, Single-PhotonConceptsAcute psychological stressMyocardial perfusionPsychological stressDepressed rangeNormal rangeAcute coronary syndrome (ACS) recurrenceSelective serotonin reuptake inhibitor medicationsStable coronary heart diseaseCoronary heart disease patientsSerotonin reuptake inhibitor medicationsImpaired myocardial perfusionTomography myocardial perfusionCoronary heart diseaseMortality risk factorsOptimal medical careHigh normal rangeReuptake inhibitor medicationsHeart disease patientsBeck Depression InventorySingle photon emissionACS recurrenceCHD prognosisInhibitor medicationVascular mechanismsMeasures of depression
2010
Sensitivity to stress-induced reproductive dysfunction is associated with a selective but not a generalized increase in activity of the adrenal axis
Herod SM, Dettmer AM, Novak MA, Meyer JS, Cameron JL. Sensitivity to stress-induced reproductive dysfunction is associated with a selective but not a generalized increase in activity of the adrenal axis. AJP Endocrinology And Metabolism 2010, 300: e28-e36. PMID: 20959528, PMCID: PMC3023200, DOI: 10.1152/ajpendo.00223.2010.Peer-Reviewed Original ResearchConceptsStress-induced reproductive dysfunctionHPA axis activityReproductive dysfunctionAxis activityHSR monkeysSS monkeysBaseline HPA axis activityChronic HPA axis activityAdrenal axis activityMetabolic stressFemale cynomolgus monkeysAcute psychological stressConcentrations of cortisolEveryday life stressDiurnal releaseAdrenal axisAdrenal weightHPA axisCommon causeCynomolgus monkeysPercent suppressionDysfunctionCortisolACTHPsychological stress
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