2025
Endpoint assessment via routinely collected data generates estimates comparable to randomized controlled trial data: analysis of a cluster-randomized trial on fall injury prevention
Ganz D, Greene E, Latham N, Kane M, Min L, Gill T, Reuben D, Peduzzi P, Esserman D. Endpoint assessment via routinely collected data generates estimates comparable to randomized controlled trial data: analysis of a cluster-randomized trial on fall injury prevention. Journal Of Clinical Epidemiology 2025, 181: 111718. PMID: 39938700, PMCID: PMC12103980, DOI: 10.1016/j.jclinepi.2025.111718.Peer-Reviewed Original ResearchRatio of hazard ratiosHazard ratioConfidence intervalsDevelop Confidence in EldersEnhanced usual careFall injury riskPrimary care practicesFall injury preventionPrimary outcomeIncreasing length of follow-upCluster randomized trialUS healthcare systemStudy dataEstimates of validityUsual careInjury preventionCare practicesMultifactorial interventionOutcome ascertainmentInjury riskCluster-randomizedCare managementRandomized Controlled Trial DataStride dataHealthcare system
2024
Primary outcomes of the enhanced, EHR-facilitated cancer symptom control (E2C2) cluster-randomized, stepped wedge, pragmatic trial.
Cheville A, Pachman D, Kroenke K, Herrin J, Grzegorczyk V, Mitchell S, Griffin J, Ridgeway J, Austin J, Smith A, Chlan L, Tofthagen C, Ruddy K. Primary outcomes of the enhanced, EHR-facilitated cancer symptom control (E2C2) cluster-randomized, stepped wedge, pragmatic trial. Journal Of Clinical Oncology 2024, 42: lba12006-lba12006. DOI: 10.1200/jco.2024.42.17_suppl.lba12006.Peer-Reviewed Original ResearchElectronic patient-reported outcome measuresCollaborative care modelElectronic health recordsNumerical rating scaleCluster-randomizedPragmatic trialSymptom burdenAssociated with adverse health outcomesCCM-based interventionsPatient-reported outcome measuresHealth service outcomesSelf-management informationClinician decision supportPrimary outcomeCancer type or stageMulti-state health systemCancer symptom controlCluster randomized trialMedical oncology clinicAdverse health outcomesUsual careCare modelCare teamSymptom managementSymptom scoresPragmatic Trial of Messaging to Providers About Treatment of Hyperlipidemia (PROMPT-LIPID): A Randomized Clinical Trial
Shah N, Ghazi L, Yamamoto Y, Kumar S, Martin M, Simonov M, Riello Iii R, Faridi K, Ahmad T, Wilson F, Desai N. Pragmatic Trial of Messaging to Providers About Treatment of Hyperlipidemia (PROMPT-LIPID): A Randomized Clinical Trial. Circulation Cardiovascular Quality And Outcomes 2024, 17: e010335. PMID: 38634282, DOI: 10.1161/circoutcomes.123.010335.Peer-Reviewed Original ResearchElectronic health recordsElectronic health record alertsHigh-risk atherosclerotic cardiovascular diseaseLipid lowering therapyAtherosclerotic cardiovascular diseasePragmatic trialCardiovascular diseaseProportion of patientsYale New Haven HealthLDL-CSecondary outcomesPrimary outcomeInternal medicine cliniciansEHR alertUsual careHealth recordsProvider levelCluster-randomizedLDL-C managementLDL-C levelsAdverse cardiovascular eventsRandomized clinical trialsTreatment of hyperlipidemiaCliniciansCardiovascular events
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