2023
Separation of B- and T-Cell-Specific Signaling Molecules Prevents Oncogenic Transformation in Lymphoid Malignancies
Ketzer F, Klemm L, Robinson M, Loucks C, Arce D, Cosgun K, Kothari S, Müschen M. Separation of B- and T-Cell-Specific Signaling Molecules Prevents Oncogenic Transformation in Lymphoid Malignancies. Blood 2023, 142: 1396. DOI: 10.1182/blood-2023-189221.Peer-Reviewed Original ResearchKinase ZAP70Transcriptional regulationTranscription factorsKinase SykDownstream activationT-cell signaling proteinsCRISPR/Cas9-mediated knockoutComparative proteomic analysisNegative selectionFunction of proteinsWild-type cellsCas9-mediated knockoutCo-expressed proteinsPre-malignant cellsT cell linesCellular fitnessTranscription machinerySLP-76Signaling proteinsMalignant transformationSignal transductionAberrant transcriptionProteomic analysisChIP-qPCRNovel key mechanism
2017
Dissecting the Role of EZH2 and H3K27me3 in Endometriosis
Colon‐Caraballo M, Soto‐Vargas J, Urrutia R, Flores I. Dissecting the Role of EZH2 and H3K27me3 in Endometriosis. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.1058.1.Peer-Reviewed Original ResearchEndometriotic lesionsHistone methyltransferase inhibitorsHistone marksEffect of EZH2 inhibitionPromoter regionChIP-qPCRPharmacological inhibition of EZH2Cells expressing high levelsWestern blottingCell linesIsoform protein expressionCellular behaviorH3K27me3 histone marksInhibition of EZH2Promoter regions of candidate genesChIP-qPCR resultsH3K27me3 antibodiesUterine cavityGynecologic conditionsEutopic endometriumEndometriotic samplesLevels of H3K27me3EZH2 inhibitionEndometriotic cellsTranscription machinery
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