2024
Dietary EPA and DHA enrichment of a high fat diet during doxorubicin-based chemotherapy attenuated neuroinflammatory gene expression in the brain of C57bl/6 ovariectomized mice
Ormiston K, Melink Z, Andridge R, Lustberg M, DeVries A, Murphy K, Emmers K, Ziouzenkova O, Belury M, Orchard T. Dietary EPA and DHA enrichment of a high fat diet during doxorubicin-based chemotherapy attenuated neuroinflammatory gene expression in the brain of C57bl/6 ovariectomized mice. Brain Behavior And Immunity 2024, 123: 370-382. PMID: 39313165, DOI: 10.1016/j.bbi.2024.09.021.Peer-Reviewed Original ResearchHOMA-IRChemotherapy-related cognitive impairmentHigh-fatDietary eicosapentaenoic acidDocosahexaenoic acidBlood-brain barrier regulationDoxorubicin-based chemotherapyFemale C57BL/6 miceLF groupEicosapentaenoic acidBody fat lossLow-fat (LFHF dietNeuroinflammatory gene expressionLipid metabolismMultiple genesReduction of oxidative stressAlterations of glucoseFat (LFHigh-fat dietGene expressionOvariectomized miceC57BL/6 miceChemotherapy agentsBreast cancerLow sucrose diets protect long-term memory and EPA & DHA enriched diets alter insulin resistance in a mouse model of chemotherapy
Ormiston K, Fitzgerald J, Andridge R, Lustberg M, DeVries A, Orchard T. Low sucrose diets protect long-term memory and EPA & DHA enriched diets alter insulin resistance in a mouse model of chemotherapy. Nutrition Research 2024, 131: 39-53. PMID: 39368285, PMCID: PMC11683824, DOI: 10.1016/j.nutres.2024.09.004.Peer-Reviewed Original ResearchLiver lipid contentMouse model of chemotherapyLipid contentBody weightLong-term memorySucrose dietLow-sucrose dietDocosahexaenoic acidInsulin resistanceChemotherapy-related cognitive impairmentMouse modelEffects of EPA+DHADoxorubicin-based chemotherapyFemale C57BL/6 miceImpact of chemotherapyAltered insulin resistanceNegatively impacts quality of lifeInsulin resistance scoreDietResistance scoreLower sucrose consumptionEPA+DHARandomized to 1Affective side effectsEicosapentaenoic acid + docosahexaenoic acid
2023
A Drosophila model relevant to chemotherapy-related cognitive impairment
Torre M, Bukhari H, Nithianandam V, Zanella C, Mata D, Feany M. A Drosophila model relevant to chemotherapy-related cognitive impairment. Scientific Reports 2023, 13: 19290. PMID: 37935827, PMCID: PMC10630312, DOI: 10.1038/s41598-023-46616-9.Peer-Reviewed Original ResearchConceptsChemotherapy-related cognitive impairmentAdverse effects of treatmentDrosophila modelChemotherapeutic agent cisplatinDisease-modifying therapiesTesting chemotherapyEffects of treatmentNeurological deficitsImmunohistochemical analysisDissection of pathwaysChemotherapy patientsAgent cisplatinHistological alterationsDrosophila tissuesAdult DrosophilaChemotherapyDrosophilaAdverse effectsGenetic approachesMemory deficitsOxidative stressCisplatinCancer survivorsDoxorubicinMechanistic dissection
2019
The dorsolateral prefrontal cortex is selectively involved in chemotherapy-related cognitive impairment in breast cancer patients with different hormone receptor expression.
Chen H, Ding K, Zhao J, Chao HH, Li CR, Cheng H. The dorsolateral prefrontal cortex is selectively involved in chemotherapy-related cognitive impairment in breast cancer patients with different hormone receptor expression. American Journal Of Cancer Research 2019, 9: 1776-1785. PMID: 31497358, PMCID: PMC6726991.Peer-Reviewed Original ResearchChemotherapy-related cognitive impairmentBreast cancer patientsHormone receptor expressionDorsolateral prefrontal cortexLeft dorsolateral prefrontal cortexCancer patientsSuperior frontal gyrusReceptor expressionFunctional connectivityPrefrontal cortexEstrogen receptorLeft precuneusCognitive impairmentFunctional magnetic resonance imaging (fMRI) examinationsMagnetic resonance imaging examinationsRight superior frontal gyrusNeuropsychological testsRight dorsolateral prefrontal cortexFunctional connectivity strengthResting-state fMRI dataER-/PRBC patientsDLPFC connectivityBreast cancerImaging examinations
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