2024
Dietary EPA and DHA enrichment of a high fat diet during doxorubicin-based chemotherapy attenuated neuroinflammatory gene expression in the brain of C57bl/6 ovariectomized mice
Ormiston K, Melink Z, Andridge R, Lustberg M, DeVries A, Murphy K, Emmers K, Ziouzenkova O, Belury M, Orchard T. Dietary EPA and DHA enrichment of a high fat diet during doxorubicin-based chemotherapy attenuated neuroinflammatory gene expression in the brain of C57bl/6 ovariectomized mice. Brain Behavior And Immunity 2024, 123: 370-382. PMID: 39313165, DOI: 10.1016/j.bbi.2024.09.021.Peer-Reviewed Original ResearchHOMA-IRChemotherapy-related cognitive impairmentHigh-fatDietary eicosapentaenoic acidDocosahexaenoic acidBlood-brain barrier regulationDoxorubicin-based chemotherapyFemale C57BL/6 miceLF groupEicosapentaenoic acidBody fat lossLow-fat (LFHF dietNeuroinflammatory gene expressionLipid metabolismMultiple genesReduction of oxidative stressAlterations of glucoseFat (LFHigh-fat dietGene expressionOvariectomized miceC57BL/6 miceChemotherapy agentsBreast cancer
2020
Effects of Omega-3 Fatty Acids on Brain Fatty Acids and Associations with Glucose Metabolism and Anxiety-Like Behavior in an Ovariectomized Mouse Model of Chemotherapy
Ormiston K, Phuwamongkolwiwat-Chu P, Fitzgerald J, Tinkai T, Lustberg M, DeVries A, Andridge R, Orchard T. Effects of Omega-3 Fatty Acids on Brain Fatty Acids and Associations with Glucose Metabolism and Anxiety-Like Behavior in an Ovariectomized Mouse Model of Chemotherapy. Current Developments In Nutrition 2020, 4: nzaa057_044. PMCID: PMC7257389, DOI: 10.1093/cdn/nzaa057_044.Peer-Reviewed Original ResearchAnxiety-like behaviorBrain AADietary eicosapentaenoic acidHigh-sucrose dietDHA dietSerum insulinDocosahexaenoic acidOmega-3Low omega-3Eicosapentaenoic acidChemotherapy injectionsInsulin resistanceMouse modelGlucose metabolismSucrose dietOmega-3 fatty acidsBrain fatty acidsHomeostatic model assessmentLower HOMA-IRDiet fed miceHigher serum insulinOvariectomized mouse modelFatty acidsOvariectomized C57BL/6 miceMore anxiety-like behavior
2017
Increasing dietary EPA and DHA influence estimated fatty acid desaturase activity in systemic organs which is reflected in the red blood cell in mice
Davidson EA, Pickens CA, Fenton JI. Increasing dietary EPA and DHA influence estimated fatty acid desaturase activity in systemic organs which is reflected in the red blood cell in mice. International Journal Of Food Sciences And Nutrition 2017, 69: 183-191. PMID: 28697636, DOI: 10.1080/09637486.2017.1348494.Peer-Reviewed Original ResearchConceptsDietary eicosapentaenoic acidEnzyme activity estimatesRed blood cellsDocosahexaenoic acidEicosapentaenoic acidDesaturase activityBlood cellsPhospholipid FA compositionDelta-6 desaturaseDHA influencesFatty acid metabolismTissue FA compositionFatty acid desaturase activitySystemic organsAdipose tissuePercent of energyFA compositionDelta 5Acid metabolismMuscleTissueMiceDifferential influenceCellsLung
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