2022
Evidence for a Conserved Function of Eukaryotic Pantothenate Kinases in the Regulation of Mitochondrial Homeostasis and Oxidative Stress
Ceccatelli Berti C, Gihaz S, Figuccia S, Choi J, Pal A, Goffrini P, Ben Mamoun C. Evidence for a Conserved Function of Eukaryotic Pantothenate Kinases in the Regulation of Mitochondrial Homeostasis and Oxidative Stress. International Journal Of Molecular Sciences 2022, 24: 435. PMID: 36613877, PMCID: PMC9820505, DOI: 10.3390/ijms24010435.Peer-Reviewed Original ResearchConceptsPantothenate kinase-associated neurodegenerationFunctional conservationMitochondrial transit peptidePantothenate kinaseNormal cellular activitiesUse of yeastOverexpression of humanTransit peptideConserved functionYeast mutantsModel organismsPanK activityCellular functionsOxidative stressCellular conditionsMitochondrial homeostasisCellular cofactorsDefective growthKinase isoformsCellular activitiesMetabolic pathwaysYeastGenesMitochondrial dysfunctionBiochemical properties
2018
Dynamic functional assembly of the Torsin AAA+ ATPase and its modulation by LAP1: a novel mode of regulation for AAA+ ATPases
Chase A, Laudermilch E, Wang J, Shigematsu H, Yokoyama T, Schlieker C. Dynamic functional assembly of the Torsin AAA+ ATPase and its modulation by LAP1: a novel mode of regulation for AAA+ ATPases. The FASEB Journal 2018, 32: 114.1-114.1. DOI: 10.1096/fasebj.2018.32.1_supplement.114.1.Peer-Reviewed Original ResearchOligomeric stateNuclear envelope defectsRobust ATPase activityExperimental Biology 2018 MeetingPresence of ATPEnvelope defectsCofactor assemblyHomotypic oligomersCellular cofactorsATP hydrolysisDynamic assemblyFunctional assemblyMolecular etiologyATPase activationLAP1Novel modeATPase activityCofactorFASEB JournalATPasesCofactor systemATPaseAssemblyDYT1 dystoniaKey role
2017
Dynamic functional assembly of the Torsin AAA+ ATPase and its modulation by LAP1
Chase AR, Laudermilch E, Wang J, Shigematsu H, Yokoyama T, Schlieker C. Dynamic functional assembly of the Torsin AAA+ ATPase and its modulation by LAP1. Molecular Biology Of The Cell 2017, 28: 2765-2772. PMID: 28814508, PMCID: PMC5638581, DOI: 10.1091/mbc.e17-05-0281.Peer-Reviewed Original Research
2007
Targeting proteinprotein interactions for HIV therapeutics
Rice A, Sutton R. Targeting proteinprotein interactions for HIV therapeutics. HIV Therapy 2007, 1: 369-385. DOI: 10.2217/17469600.1.4.369.Peer-Reviewed Original ResearchProtein-protein interactionsCellular cofactorsFuture drug screensProteinprotein interactionsViral envelope proteinsHIV drugsAnti-HIV drug developmentReplication cycleVirus-cell bindingEnvelope proteinViral reverse transcriptaseReverse transcriptaseCellular coreceptorCofactorCell bindingHIV-1Protease enzymeHIV therapeuticsDrug developmentUS FDADrug screensDrugsProteinTargetInteraction
1996
Identification of a Cellular Protein That Specifically Interacts with the Essential Cysteine Region of the HIV-1 Tat Transactivator
KAMINE J, ELANGOVAN B, SUBRAMANIAN T, COLEMAN D, CHINNADURAI G. Identification of a Cellular Protein That Specifically Interacts with the Essential Cysteine Region of the HIV-1 Tat Transactivator. Virology 1996, 216: 357-366. PMID: 8607265, DOI: 10.1006/viro.1996.0071.Peer-Reviewed Original ResearchMeSH KeywordsAcetyltransferasesAmino Acid SequenceBase SequenceCloning, MolecularConserved SequenceCysteineDNA, ComplementaryEscherichia coliGene Expression Regulation, ViralGene Products, tatHeLa CellsHistone AcetyltransferasesHIV-1HumansLysine Acetyltransferase 5Molecular Sequence DataPoint MutationPromoter Regions, GeneticProtein BindingProteinsSaccharomyces cerevisiaetat Gene Products, Human Immunodeficiency VirusConceptsHIV gene expressionGene expressionN-terminal 31 amino acidsEssential cysteine residueFull-length cDNATat activation domainHIV-1 Tat transactivatorPartial cDNA cloneHIV-1 promoterActivation domainCellular proteinsTAT activityAbolishes interactionCysteine regionCDNA clonesCellular cofactorsCysteine residuesTransient expressionTat transactivationTat transactivatorHIV-1 TatAmino acidsInteractive cloningProteinPromoter
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