2025
Transient Upregulation of Procaspase-3 during Oligodendrocyte Fate Decisions
Kamen Y, Chapman T, Piedra E, Ciolkowski M, Hill R. Transient Upregulation of Procaspase-3 during Oligodendrocyte Fate Decisions. Journal Of Neuroscience 2025, 45: e2066242025. PMID: 39837665, PMCID: PMC11924999, DOI: 10.1523/jneurosci.2066-24.2025.Peer-Reviewed Original ResearchProcaspase-3Fate decisionsOligodendrocyte precursor cellsCell death mechanismsNeurodegenerative conditionsOligodendrocyte differentiationSurvival decisionsCellular checkpointsDeath mechanismsMolecular markersPrecursor cellsOligodendrocyte markersPromote oligodendrocyte differentiationPharmacological inhibitionDifferentiation stageTransient upregulationDifferentiationZymogenCellsOligodendrocyte densityMorphological stateMale miceOligodendrocyte deathMyelin dysfunctionMarkers
2021
Unsupervised discovery of dynamic cell phenotypic states from transmitted light movies
Nguyen P, Chien S, Dai J, Monnat R, Becker P, Kueh H. Unsupervised discovery of dynamic cell phenotypic states from transmitted light movies. PLOS Computational Biology 2021, 17: e1009626. PMID: 34968384, PMCID: PMC8754342, DOI: 10.1371/journal.pcbi.1009626.Peer-Reviewed Original ResearchConceptsCell's phenotypic statePhenotypic statesLatent cell representationsPatient-derived acute myeloid leukemia cellsSingle-cell analysis methodsMyeloid leukemia cellsAcute myeloid leukemia cellsPhenotypic readoutsBlood cell typesModern biologyCell statesMorphological readoutsLeukemia cellsCell typesRate inferenceMorphological stateBiologyVariational auto-encoder architectureCellsHeterogeneous populationStem-cellIdentificationTransition ratesState heterogeneity
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