2022
Different radiation responses induced by acquired gefitinib resistance in a non-small-cell lung cancer cell line
Kim J, Chowdhury T, Park H, Kim S, Lee C, Park C, Kim J, Kim I, Kim B, Kim T, Ku J, Lee J. Different radiation responses induced by acquired gefitinib resistance in a non-small-cell lung cancer cell line. Brain Tumor Research And Treatment 2022, 10: s366. DOI: 10.14791/btrt.2022.10.f-1244.Peer-Reviewed Original Research
2019
The α7 nicotinic receptor silent agonist R-47 prevents and reverses paclitaxel-induced peripheral neuropathy in mice without tolerance or altering nicotine reward and withdrawal
Toma W, Kyte SL, Bagdas D, Jackson A, Meade JA, Rahman F, Chen ZJ, Del Fabbro E, Cantwell L, Kulkarni A, Thakur GA, Papke RL, Bigbee JW, Gewirtz DA, Damaj MI. The α7 nicotinic receptor silent agonist R-47 prevents and reverses paclitaxel-induced peripheral neuropathy in mice without tolerance or altering nicotine reward and withdrawal. Experimental Neurology 2019, 320: 113010. PMID: 31299179, PMCID: PMC6708482, DOI: 10.1016/j.expneurol.2019.113010.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyPeripheral neuropathyNicotine rewardPaclitaxel treatmentRewarding effectsTreatment of CIPNPaclitaxel-induced mechanical hypersensitivityTumor-bearing NSG micePaclitaxel-induced peripheral neuropathyNon-small cell lung cancer cell linesCell lung cancer cell linesA549 non-small cell lung cancer cell lineMecamylamine-precipitated withdrawalAntitumor activityIntraepidermal nerve fibersLung cancer cell linesLung tumor growthNSCLC cell viabilityTumor-bearing miceIntrinsic rewarding effectsPlace preference testCancer cell linesConditioned place preference testMechanical hypersensitivityAgonist R
2016
Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells
Lopez-Sambrooks C, Shrimal S, Khodier C, Flaherty DP, Rinis N, Charest JC, Gao N, Zhao P, Wells L, Lewis TA, Lehrman MA, Gilmore R, Golden JE, Contessa JN. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nature Chemical Biology 2016, 12: 1023-1030. PMID: 27694802, PMCID: PMC5393272, DOI: 10.1038/nchembio.2194.Peer-Reviewed Original ResearchMeSH KeywordsBenzamidesCell Cycle CheckpointsCell Line, TumorCell ProliferationCellular SenescenceDose-Response Relationship, DrugEnzyme InhibitorsHexosyltransferasesHigh-Throughput Screening AssaysHumansMembrane ProteinsMolecular StructureReceptor Protein-Tyrosine KinasesStructure-Activity RelationshipSulfonamidesConceptsCell lung cancer cell linesLung cancer cell linesCancer cell linesCell cycle arrestNGI-1Tumor cellsCell linesEGFR
2009
Lung cancer osteopontin isoforms exhibit angiogenic functional heterogeneity
Blasberg JD, Goparaju CM, Pass HI, Donington JS. Lung cancer osteopontin isoforms exhibit angiogenic functional heterogeneity. Journal Of Thoracic And Cardiovascular Surgery 2009, 139: 1587-1593. PMID: 19818970, PMCID: PMC2875279, DOI: 10.1016/j.jtcvs.2009.08.016.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factor (VEGF) secretionGrowth factor secretionCell lung cancerLung cancer angiogenesisEnzyme-linked immunosorbentOsteopontin isoformsFactor secretionLung cancerNon-small cell lung cancer (NSCLC) pathogenesisCancer angiogenesisCell linesNon-small cell lung cancerVascular endothelial growth factor levelsMRNA expressionCell lung cancer cell linesLung cancer pathogenesisGrowth factor levelsLung cancer cell linesVascular endothelial growth factorTubule lengthImmortalized bronchial epithelial cell lineEndothelial growth factorBronchial epithelial cell lineOsteopontin secretionCancer cell lines
1987
myc family oncogene amplification in tumor cell lines established from small cell lung cancer patients and its relationship to clinical status and course.
Johnson B, Ihde D, Makuch R, Gazdar A, Carney D, Oie H, Russell E, Nau M, Minna J. myc family oncogene amplification in tumor cell lines established from small cell lung cancer patients and its relationship to clinical status and course. Journal Of Clinical Investigation 1987, 79: 1629-1634. PMID: 3034978, PMCID: PMC424486, DOI: 10.1172/jci112999.Peer-Reviewed Original ResearchConceptsMyc family DNA amplificationPatient tumorsTumor cell linesC-myc amplificationCell linesSmall cell lung cancer patientsCell lung cancer patientsSmall cell lung cancer cell linesCell lung cancer cell linesExtensive-stage patientsLung cancer patientsLung cancer cell linesCancer cell linesRelapsed patientsStage patientsClinical statusCancer patientsChemotherapy treatmentPatientsTumorsDNA amplificationOncogene amplification
1986
Changes in the phenotype of human small cell lung cancer cell lines after transfection and expression of the c-myc proto-oncogene.
Johnson B, Battey J, Linnoila I, Becker K, Makuch R, Snider R, Carney D, Minna J. Changes in the phenotype of human small cell lung cancer cell lines after transfection and expression of the c-myc proto-oncogene. Journal Of Clinical Investigation 1986, 78: 525-532. PMID: 3016030, PMCID: PMC423589, DOI: 10.1172/jci112604.Peer-Reviewed Original ResearchConceptsSmall cell lung cancer cell linesCell lung cancer cell linesLung cancer cell linesCancer cell linesBombesin-like immunoreactivityLarge cell morphologyC-myc messenger RNAC-myc expressionC-MycCell linesSmall cell lung cancerHuman small cell lung cancer cell linesCell lung cancerSmall cell lung cancer linesCell lung cancer linesMessenger RNALung cancer linesC-myc amplificationC-myc geneLung cancerVariant phenotypesCloning efficiencyDecarboxylase levelsCancer linesBiologic properties
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply