Limited Efficacy and Unacceptable Toxicity of Cyclophosphamide for the Induction of Mixed Chimerism and Renal Allograft Tolerance in Cynomolgus Monkeys
Sogawa H, Boskovic S, Nadazdin O, Abrahamian G, Colvin R, Sachs D, Cosimi A, Kawai T. Limited Efficacy and Unacceptable Toxicity of Cyclophosphamide for the Induction of Mixed Chimerism and Renal Allograft Tolerance in Cynomolgus Monkeys. Transplantation 2008, 86: 615-619. PMID: 18724233, PMCID: PMC2786005, DOI: 10.1097/tp.0b013e3181821bac.Peer-Reviewed Original ResearchConceptsTotal body irradiationRenal allograft toleranceInduction of mixed chimerismTotal body irradiation groupMixed chimerismAllograft toleranceCynomolgus monkeysCD154 blockadeAbsolute B-cell countNonmyeloablative conditioning regimenB-cell countsB-cell lymphomaToxicity of cyclophosphamideDose-dependent neutropeniaLong-term survivalConditioning regimenNonmyeloablative regimenMultilineage chimerismHematopoietic recoveryBody irradiationToxicity of CPLimited efficacyCyclophosphamideTotal doseChimerism
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply