A non-catalytic role of IPMK is required for PLCγ1 activation in T cell receptor signaling by stabilizing the PLCγ1-Sam68 complex
Hong S, Kim K, Shim Y, Park J, Choi S, Min H, Lee S, Song J, Kang S, Jeong W, Seong R, Kim S. A non-catalytic role of IPMK is required for PLCγ1 activation in T cell receptor signaling by stabilizing the PLCγ1-Sam68 complex. Cell Communication And Signaling 2024, 22: 526. PMID: 39478550, PMCID: PMC11524019, DOI: 10.1186/s12964-024-01907-0.Peer-Reviewed Original ResearchConceptsInositol polyphosphate multikinaseT cell receptor signalingSrc family kinasesT cell receptorYeast two-hybrid screenFunctional protein-protein interactionsSrc-associated substrateTwo-hybrid screenNon-catalytic roleCD4+ T cellsProtein-protein interactionsPhosphatidylinositol 4,5-bisphosphateGrowth factor signalingC gamma 1Dominant-negative peptideNon-catalytic activitiesDownstream Signaling PathwaysQuantitative real-time PCRStimulation of T cell receptorSubstrate specificityPleiotropic enzymeProtein complexesFamily kinasesCo-ImmunoprecipitationT cells
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