Upregulation of transient receptor potential melastatin 4 (TRPM4) in ventricular fibroblasts from heart failure patients
Feng J, Zong P, Yan J, Yue Z, Li X, Smith C, Ai X, Yue L. Upregulation of transient receptor potential melastatin 4 (TRPM4) in ventricular fibroblasts from heart failure patients. Pflügers Archiv - European Journal Of Physiology 2021, 473: 521-531. PMID: 33594499, PMCID: PMC8857941, DOI: 10.1007/s00424-021-02525-2.Peer-Reviewed Original ResearchConceptsTransient receptor potential melastatin 4Heart failure patientsControl individualsCardiac conductionTRPM4 activityFailure patientsNonselective monovalent cation channelImpaired cardiac conductionIntracellular calcium activityTRP channel superfamilyMonovalent cation channelLoss-of-function mutationsCardiac myocytesVentricular fibroblastsCation channelsConduction defectsHeart failureCardiac fibrogenesisTGFB1 treatmentCardiac fibroblastsGain-of-functionCalcium activityPatientsHF fibroblastsChannel superfamily
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