2024
Long-term second-generation antipsychotics decreases bone formation and resorption in male patients with schizophrenia
Wang F, Li H, Yi K, Wu Y, Bian Q, Guo B, Luo X, Kang Y, Wu Q, Ma Q. Long-term second-generation antipsychotics decreases bone formation and resorption in male patients with schizophrenia. Psychopharmacology 2024, 241: 1771-1780. PMID: 38647696, DOI: 10.1007/s00213-024-06592-y.Peer-Reviewed Original ResearchConceptsSecond-generation antipsychoticsBone turnover biomarkersEffects of antipsychoticsInteraction effect of groupCTX-1Effect of groupMale patientsBone fragilityBone resorptionC-terminal telopeptide of type I collagenSGA treatmentFasting peripheral blood samplesTelopeptide of type I collagenSchizophreniaIncreased risk of bone fragilityChinese male patientAntipsychoticsC-terminal telopeptideBalance of bone metabolismRisk of bone fragilityBone formationBalance of bone formationChronic patientsTime-dependent mannerCTX-1 concentrations
2021
Resolution of sclerotic lesions of dysosteosclerosis due to biallelic SLC29A3 variant in a Turkish girl
Alkaya D, Akpınar E, Bilguvar K, Tüysüz B. Resolution of sclerotic lesions of dysosteosclerosis due to biallelic SLC29A3 variant in a Turkish girl. American Journal Of Medical Genetics Part A 2021, 185: 2271-2277. PMID: 33837634, DOI: 10.1002/ajmg.a.62198.Peer-Reviewed Original ResearchConceptsCortical thickeningShort statureThree-year-old girlLarge anterior fontanelleLong bone metaphysisDiffuse sclerosisFracture historyElbow contractureAnterior fontanelleSclerotic lesionsBone fragilitySpontaneous resolutionBone metaphysisMild sclerosisSkeletal radiographsSclerosisMelanocytic neviBone dysplasiaSkull baseHeterogeneous disorderSLC29A3 mutationsVertebral endplatesBiallelic mutationsTurkish girlPelvic bonesProgranulin promotes bone fracture healing via TNFR pathways in mice with type 2 diabetes mellitus
Ding Y, Wei J, Hettinghouse A, Li G, Li X, Einhorn T, Liu C. Progranulin promotes bone fracture healing via TNFR pathways in mice with type 2 diabetes mellitus. Annals Of The New York Academy Of Sciences 2021, 1490: 77-89. PMID: 33543485, PMCID: PMC8138780, DOI: 10.1111/nyas.14568.Peer-Reviewed Original ResearchConceptsType 2 diabetes mellitusRole of progranulinBone fracture healingFracture healingDiabetes mellitusT2DM modelType 1 diabetic conditionAnti-inflammatory activityTranscription-polymerase chain reactionLocal administrationBone marrow cellsExogenous progranulinMKR micePGRN effectsPrimary bone marrow cellsFracture riskDiabetic conditionsPGRN mRNABone fragilityImmunohistochemical stainingMetabolic disordersRecombinant progranulinBone fracturesProgranulinTherapeutic potential
2019
Human Heterozygous ENPP1 Deficiency Is Associated With Early Onset Osteoporosis, a Phenotype Recapitulated in a Mouse Model of Enpp1 Deficiency
Oheim R, Zimmerman K, Maulding ND, Stürznickel J, von Kroge S, Kavanagh D, Stabach PR, Kornak U, Tommasini SM, Horowitz MC, Amling M, Thompson D, Schinke T, Busse B, Carpenter TO, Braddock DT. Human Heterozygous ENPP1 Deficiency Is Associated With Early Onset Osteoporosis, a Phenotype Recapitulated in a Mouse Model of Enpp1 Deficiency. Journal Of Bone And Mineral Research 2019, 35: 528-539. PMID: 31805212, PMCID: PMC7184798, DOI: 10.1002/jbmr.3911.Peer-Reviewed Original ResearchConceptsAutosomal recessive hypophosphatemic rickets type 2ENPP1 deficiencyEarly-onset osteoporosisGene-dose effectOnset osteoporosisAsj/Bone mineral density scansBone mineralization disturbancesRenal phosphate wastingCortical boneDose effectMild osteomalaciaMineralization disturbancesFGF23 levelsMild elevationPlasma FGF23Arterial calcificationBone massPhosphate wastingSkeletal manifestationsBone fragilityThoracic spineWild-type family membersType 2Adult men
2016
Novel anatomic adaptation of cortical bone to meet increased mineral demands of reproduction
Macica CM, King HE, Wang M, McEachon CL, Skinner CW, Tommasini SM. Novel anatomic adaptation of cortical bone to meet increased mineral demands of reproduction. Bone 2016, 85: 59-69. PMID: 26825813, PMCID: PMC7429445, DOI: 10.1016/j.bone.2015.12.056.Peer-Reviewed Original ResearchConceptsHyp miceMineral homeostasisElevated serum PTHMaternal bone massMineralized trabecular boneIntestinal calcium absorptionCortical boneWild-type miceSerum PTHCalcitriol productionFemale patientsMaternal skeletonPostnatal nutritionCalcium absorptionBone resorptionFracture riskMaternal adaptationBone massBone fragilityMurine modelIntracortical porosityUnaffected miceMouse modelMMP-13Fetal development
2008
Proximal Femur Mechanical Adaptation to Weight Gain in Late Adolescence: A Six‐Year Longitudinal Study1*
Petit M, Beck T, Hughes J, Lin H, Bentley C, Lloyd T. Proximal Femur Mechanical Adaptation to Weight Gain in Late Adolescence: A Six‐Year Longitudinal Study1*. Journal Of Bone And Mineral Research 2008, 23: 180-188. PMID: 17937533, PMCID: PMC2665698, DOI: 10.1359/jbmr.071018.Peer-Reviewed Original ResearchConceptsEffect of weight gainBone cross-sectional areaWeight gainersIncreased BMDLean massBone bending strengthWeight gainBody weightWG groupProximal femur DXA scansCross-sectional areaProximal femur BMDTotal body scanTotal body leanIncreased bone fragilitySubperiosteal expansionSW groupBone strength indexLate adolescenceFemur BMDAreal BMDDXA scansHigher BMDBone fragilityHormone levels
1987
BONE FRAGILITY, CRANIOSYNOSTOSIS, HYDROCEPHALUS AND OCULAR PROPTOSIS: FURTHER OBSERVATIONS ON A NEWLY RECOGNIZED TYPE OF OSTEOGENESIS IMPERFECTA (OI)
Cole D, Carpenter T. BONE FRAGILITY, CRANIOSYNOSTOSIS, HYDROCEPHALUS AND OCULAR PROPTOSIS: FURTHER OBSERVATIONS ON A NEWLY RECOGNIZED TYPE OF OSTEOGENESIS IMPERFECTA (OI). Pediatric Research 1987, 21: 226-226. DOI: 10.1203/00006450-198704010-00360.Peer-Reviewed Original ResearchOcular proptosisOsteogenesis imperfectaPoor wound healingConnective tissue involvementYears of ageMonths of ageRecognized typesClinical featuresCompression fracturesEasy bruisingNew bone formationBone resorptionDiaphyseal fracturesTissue involvementBony deformityBone fragilityBlue scleraeBone deformitiesSimilar facial featuresJoint laxityBone volumeExtensive demineralizationUnrelated infantsHigh-pitched voiceNew casesBone fragility, craniosynostosis, ocular proptosis, hydrocephalus, and distinctive facial features: A newly recognized type of osteogenesis imperfecta
Cole E, Carpenter T. Bone fragility, craniosynostosis, ocular proptosis, hydrocephalus, and distinctive facial features: A newly recognized type of osteogenesis imperfecta. The Journal Of Pediatrics 1987, 110: 76-80. PMID: 3794889, DOI: 10.1016/s0022-3476(87)80292-5.Peer-Reviewed Original ResearchConceptsDistinctive facial featuresOsteogenesis imperfectaOcular proptosisMultiple compression fracturesWeight-bearing bonesDistinctive dysmorphic featuresBone biopsyCompression fracturesNew bone formationBone resorptionDiaphyseal fracturesBone fragilityBone deformitiesBone volumeExtensive demineralizationNew casesDysmorphic featuresFirst birthdayHydrocephalusBone formationLong bonesProptosisMultiple fracturesImperfectaFurther elucidation
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