Down Syndrome Alters Type-III IFN and Pro-Inflammatory Airway Epithelial Responses to RSV Infection.
Chorvinsky E, Bhattacharya S, Bera B, Welham A, Ismat K, Lawlor C, Preciado D, Gomez J, Morizono H, Pillai D, Gutierrez M, Jaiswal J, Nino G. Down Syndrome Alters Type-III IFN and Pro-Inflammatory Airway Epithelial Responses to RSV Infection. American Journal Of Respiratory Cell And Molecular Biology 2025 PMID: 40587878, DOI: 10.1165/rcmb.2025-0068oc.Peer-Reviewed Original ResearchAirway epithelial cellsRSV infectionType III IFNsViral infectionDown syndromeNasal airway epithelial cellsResponse to RSV infectionSeverity of RSV infectionRSV-induced responsesSevere viral bronchiolitisAirway immune responsesRespiratory syncytial virusPro-inflammatory statePro-inflammatory cytokinesPro-inflammatory responseEnhanced viral infectionType III IFN responseViral bronchiolitisSyncytial virusImmunological basisPediatric donorsPrimary sitePro-inflammatoryImmune responseEpithelial cells
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