Pathological Calcium Signaling in Traumatic Brain Injury and Alzheimer’s Disease: From Acute Neuronal Injury to Chronic Neurodegeneration
Neuschmid S, Schallerer C, Ehrlich B, McGuone D. Pathological Calcium Signaling in Traumatic Brain Injury and Alzheimer’s Disease: From Acute Neuronal Injury to Chronic Neurodegeneration. International Journal Of Molecular Sciences 2025, 26: 9245. PMID: 41009808, PMCID: PMC12471116, DOI: 10.3390/ijms26189245.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseCalcium-dependent protease calpainPharmacological inhibitionCalcium signalingTau hyperphosphorylationAmyloid-bLoss of calcium homeostasisProtein misfoldingCalcium-dependent enzymesSignaling proteinsAD riskProtease calpainAD modelProtease networkDisrupted calcium signalingTraumatic brain injuryUpstream driversEnzyme activityPathological calcium signalingSynaptic architectureCalcium dysregulationAxonal transportNeuronal deathEssential scaffoldsCalcium homeostasis
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply