Comparative efficacy, tolerability, and acceptability of pharmacological interventions for the treatment of children, adolescents, and young adults with Tourette's syndrome: a systematic review and network meta-analysis
Farhat L, Behling E, Landeros-Weisenberger A, Levine J, Macul Ferreira de Barros P, Wang Z, Bloch M. Comparative efficacy, tolerability, and acceptability of pharmacological interventions for the treatment of children, adolescents, and young adults with Tourette's syndrome: a systematic review and network meta-analysis. The Lancet Child & Adolescent Health 2022, 7: 112-126. PMID: 36528030, DOI: 10.1016/s2352-4642(22)00316-9.Peer-Reviewed Original ResearchConceptsAntipsychotic drugsTourette syndromeComorbid attention-deficit hyperactivity disorderSecond-generation antipsychotic drugsModerate certainty of evidenceAttention-deficit hyperactivity disorderCertainty of evidenceNetwork Meta-AnalysisPharmacological interventionsSeverity of tic symptomsObsessive-compulsive disorderIndividual medicationsRandomised controlled trialsFirst-generationDiscontinuation due to adverse eventsSecond-generationAntipsychotic medicationControlled TrialsModerate certaintyHyperactivity disorderMeta-analysisTic symptomsChoice of medicationMedication categoriesTourette
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