2016
Hypophosphatemia promotes lower rates of muscle ATP synthesis
Pesta DH, Tsirigotis DN, Befroy DE, Caballero D, Jurczak MJ, Rahimi Y, Cline GW, Dufour S, Birkenfeld AL, Rothman DL, Carpenter TO, Insogna K, Petersen KF, Bergwitz C, Shulman GI. Hypophosphatemia promotes lower rates of muscle ATP synthesis. The FASEB Journal 2016, 30: 3378-3387. PMID: 27338702, PMCID: PMC5024687, DOI: 10.1096/fj.201600473r.Peer-Reviewed Original ResearchConceptsMuscle ATP synthesisATP synthesisMuscle weaknessIsolated muscle mitochondriaSolute carrier familyWild-type littermate controlsSolute carrier family 34Carrier familyLower ratesInsulin-stimulated ratesMuscle mitochondriaChronic hypophosphatemiaHeart failureHypophosphatemic groupHypophosphatemic miceHypophosphatemiaLittermate controlsKnockout miceBlood PLow ratePlasma PPatientsSimilar findingsMember 1Plasma inorganic phosphate
2014
Age-Associated Bone Disease in Factor VIII-Deficient Mice
Larson E, Iwaniec U, Holmgren S, Turner R, Recht M, Taylor J. Age-Associated Bone Disease in Factor VIII-Deficient Mice. Blood 2014, 124: 2798. DOI: 10.1182/blood.v124.21.2798.2798.Peer-Reviewed Original ResearchFVIII-deficient miceReceptor activator of nuclear factor kappa BWild-type littermate controlsPeak bone massBone mineral densityFVIII deficiencyBone diseaseLittermate controlsSkeletal healthBiomechanical strengthMineral densityBone massFactor VIII (FVIII)-deficient miceFactor VIII-deficient miceReceptor activator of nuclear factor kappa-B ligandFemoral bone mineral densityAmeliorating bone diseasesImpact skeletal healthTumor necrosis factor-alphaBiomarkers of bone formationActivation of nuclear factor kappa BWild-type littermatesBone marrow cellsRT-PCRGene expression
2009
Functional outcome is impaired following traumatic brain injury in aging Nogo-A/B-deficient mice
Marklund N, Morales D, Clausen F, Hånell A, Kiwanuka O, Pitkänen A, Gimbel DA, Philipson O, Lannfelt L, Hillered L, Strittmatter SM, McIntosh TK. Functional outcome is impaired following traumatic brain injury in aging Nogo-A/B-deficient mice. Neuroscience 2009, 163: 540-551. PMID: 19555742, PMCID: PMC2756649, DOI: 10.1016/j.neuroscience.2009.06.042.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryHemispheric tissue lossNeurological motor functionWT miceBrain injuryMotor functionCortical impact (CCI) TBILittermate controlsAge-matched wild-type littermate controlsMyelin stainingTissue lossMWM taskWild-type littermate controlsCortical lesion volumeAxonal growth inhibitorsRole of NogoMyelin-derived inhibitorAbsence of NogoNeurological motorPoor prognosisFunctional outcomeHemispheric tissuePathophysiological responsesWT littermatesDeficient mice
2007
Increased Thalamocortical Synaptic Response and Decreased Layer IV Innervation in GAP-43 Knockout Mice
Albright MJ, Weston MC, Inan M, Rosenmund C, Crair MC. Increased Thalamocortical Synaptic Response and Decreased Layer IV Innervation in GAP-43 Knockout Mice. Journal Of Neurophysiology 2007, 98: 1610-1625. PMID: 17581849, DOI: 10.1152/jn.00219.2007.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic potentialsField excitatory postsynaptic potentialsGAP-43Thalamocortical synapsesSynaptic responsesCompetitive glutamate receptor antagonistN-methyl-D-aspartate receptorsAcute brain slice preparationBarrel map formationThalamocortical synaptic responsesWild-type littermate controlsGlutamate receptor antagonistsBrain slice preparationGrowth-associated proteinThalamic innervationThalamic neuronsBarrel mapReceptor antagonistIsoxazolepropionate (AMPA) receptorsPostsynaptic potentialsLayer IVSlice preparationBarrel cortexSynaptic transmissionAMPAR functionDevelopmental differences in the responses of IL-6 and IL-13 transgenic mice exposed to hyperoxia
Choo-Wing R, Nedrelow JH, Homer RJ, Elias JA, Bhandari V. Developmental differences in the responses of IL-6 and IL-13 transgenic mice exposed to hyperoxia. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2007, 293: l142-l150. PMID: 17400600, DOI: 10.1152/ajplung.00434.2006.Peer-Reviewed Original ResearchConceptsIL-13 transgenic miceIL-6Transgenic miceTracheal aspirate levelsWild-type littermate controlsIL-6 levelsRespiratory distress syndromeAngiogenic factor expressionLung injuryDistress syndromePremature neonatesTracheal aspiratesAdverse outcomesIL-13Human neonatesProtective effectSurvival advantageLittermate controlsAdult miceClinical relevanceTUNEL stainingCytoprotective effectsNewborn animalsMature miceFactor expression
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