Age-Associated Bone Disease in Factor VIII-Deficient Mice
Larson E, Iwaniec U, Holmgren S, Turner R, Recht M, Taylor J. Age-Associated Bone Disease in Factor VIII-Deficient Mice. Blood 2014, 124: 2798. DOI: 10.1182/blood.v124.21.2798.2798.Peer-Reviewed Original ResearchFVIII-deficient miceReceptor activator of nuclear factor kappa BWild-type littermate controlsPeak bone massBone mineral densityFVIII deficiencyBone diseaseLittermate controlsSkeletal healthBiomechanical strengthMineral densityBone massFactor VIII (FVIII)-deficient miceFactor VIII-deficient miceReceptor activator of nuclear factor kappa-B ligandFemoral bone mineral densityAmeliorating bone diseasesImpact skeletal healthTumor necrosis factor-alphaBiomarkers of bone formationActivation of nuclear factor kappa BWild-type littermatesBone marrow cellsRT-PCRGene expression
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