2016
Lipid Geometry and Bilayer Curvature Modulate LC3/GABARAP-Mediated Model Autophagosomal Elongation
Landajuela A, Hervás JH, Antón Z, Montes LR, Gil D, Valle M, Rodriguez JF, Goñi FM, Alonso A. Lipid Geometry and Bilayer Curvature Modulate LC3/GABARAP-Mediated Model Autophagosomal Elongation. Biophysical Journal 2016, 110: 411-422. PMID: 26789764, PMCID: PMC4724631, DOI: 10.1016/j.bpj.2015.11.3524.Peer-Reviewed Original ResearchConceptsMembrane fusionCryo-electron microscopy observationsFull membrane fusionNegative intrinsic curvature lipidsCurvature-inducing lipidsImportant catabolic pathwayMultiple fusion eventsAtg8 homologsMembrane tetheringGABARAP proteinsLytic compartmentAP biogenesisGATE-16Fusion eventsIntervesicular mixingCatabolic pathwayMembrane expansionVesicle aggregationMolecular mechanismsLipid geometryVesicle diameterHuman diseasesIntervesicular lipid mixingImportant regulatorLarge vesicles
2014
Lack of recombinant factor VIII B‐domain induces phospholipid vesicle aggregation: implications for the immunogenicity of factor VIII
Grushin K, Miller J, Dalm D, Parker E, Healey J, Lollar P, Stoilova-McPhie S. Lack of recombinant factor VIII B‐domain induces phospholipid vesicle aggregation: implications for the immunogenicity of factor VIII. Haemophilia 2014, 20: 723-731. PMID: 24750465, PMCID: PMC4149818, DOI: 10.1111/hae.12421.Peer-Reviewed Original ResearchConceptsFVIII formsB domainFVIII-BDDPhospholipid vesicle aggregationFactor VIII B domainCryo-electron microscopyMembrane-bound statePhospholipid vesiclesMembrane-bound formSerine protease factor IXaPhysiological conditionsFVIII B domainSecondary structure distributionCryo-EMVesicle aggregationBiophysical propertiesCircular dichroismProtein therapeuticsVesiclesTenase complexPhospholipid membranesPlatelet surfaceHuman factor VIIIFactor IXaHereditary bleeding disorders
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