2025
OTUD6B Regulates Ventricular Chamber Maturation and Is Required for Mouse Embryonic Development
Li Y, Zambrano-Carrasco J, Cui Y, Li J, Su H. OTUD6B Regulates Ventricular Chamber Maturation and Is Required for Mouse Embryonic Development. Physiology 2025, 40: 0884. DOI: 10.1152/physiol.2025.40.s1.0884.Peer-Reviewed Original ResearchVentricular septal defectVentricular chamber developmentCell cycle regulationCell cycle progressionCardiac defectsSeptal defectCycle regulationCycle progressionSignificant cardiac defectsVentricular chamber maturationDefective cell cycle progressionCongenital heart defectsRegulating protein stabilityAbnormal cell cycle progressionPostnatal day 1Regulating cardiomyocyte proliferationSevere cardiac phenotypeIncreased cardiac stiffnessS-phase arrestMouse embryonic developmentUnbiased transcriptome analysisMyocardial hypoplasiaHeart defectsFatty acid metabolismCardiac phenotype
2013
Modeling the Neurovascular Niche: Unbiased Transcriptome Analysis of the Murine Subventricular Zone in Response to Hypoxic Insult
Li Q, Canosa S, Flynn K, Michaud M, Krauthammer M, Madri JA. Modeling the Neurovascular Niche: Unbiased Transcriptome Analysis of the Murine Subventricular Zone in Response to Hypoxic Insult. PLOS ONE 2013, 8: e76265. PMID: 24146847, PMCID: PMC3795763, DOI: 10.1371/journal.pone.0076265.Peer-Reviewed Original ResearchConceptsSubventricular zoneRepair/recoveryChronic hypoxiaPremature infant populationMurine subventricular zoneEarly intervention approachesNeurodevelopmental handicapPremature infantsNeurovascular nicheHypoxic insultCD1 miceInfant populationMotor responsivenessCNS tissueDisease severityMRNA expressionUnbiased transcriptome analysisDifferent behavioral parametersNeural functionMouse strainsDifferential responseHypoxiaHypoxic conditionsRange of responsivenessIntervention approaches
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