OTUD6B Regulates Ventricular Chamber Maturation and Is Required for Mouse Embryonic Development
Li Y, Zambrano-Carrasco J, Cui Y, Li J, Su H. OTUD6B Regulates Ventricular Chamber Maturation and Is Required for Mouse Embryonic Development. Physiology 2025, 40: 0884. DOI: 10.1152/physiol.2025.40.s1.0884.Peer-Reviewed Original ResearchVentricular septal defectVentricular chamber developmentCell cycle regulationCell cycle progressionCardiac defectsSeptal defectCycle regulationCycle progressionSignificant cardiac defectsVentricular chamber maturationDefective cell cycle progressionCongenital heart defectsRegulating protein stabilityAbnormal cell cycle progressionPostnatal day 1Regulating cardiomyocyte proliferationSevere cardiac phenotypeIncreased cardiac stiffnessS-phase arrestMouse embryonic developmentUnbiased transcriptome analysisMyocardial hypoplasiaHeart defectsFatty acid metabolismCardiac phenotype
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