OTUD6B Regulates Ventricular Chamber Maturation and Is Required for Mouse Embryonic Development
Li Y, Zambrano-Carrasco J, Cui Y, Li J, Su H. OTUD6B Regulates Ventricular Chamber Maturation and Is Required for Mouse Embryonic Development. Physiology 2025, 40: 0884. DOI: 10.1152/physiol.2025.40.s1.0884.Peer-Reviewed Original ResearchVentricular septal defectVentricular chamber developmentCell cycle regulationCell cycle progressionCardiac defectsSeptal defectCycle regulationCycle progressionSignificant cardiac defectsVentricular chamber maturationDefective cell cycle progressionCongenital heart defectsRegulating protein stabilityAbnormal cell cycle progressionPostnatal day 1Regulating cardiomyocyte proliferationSevere cardiac phenotypeIncreased cardiac stiffnessS-phase arrestMouse embryonic developmentUnbiased transcriptome analysisMyocardial hypoplasiaHeart defectsFatty acid metabolismCardiac phenotypeRBX1-Cullin RING Ubiquitin Ligases Are Indispensable For Perinatal Cardiac Development Through Regulating The Hippo-YAP Signaling Pathway
Zambrano-Carrasco J, Jiao K, Li J, Su H. RBX1-Cullin RING Ubiquitin Ligases Are Indispensable For Perinatal Cardiac Development Through Regulating The Hippo-YAP Signaling Pathway. Physiology 2025, 40: 0183. DOI: 10.1152/physiol.2025.40.s1.0183.Peer-Reviewed Original ResearchCullin-RING ubiquitin E3 ligasesCullin proteinsCardiac morphologic abnormalitiesHippo-YAPCardiac morphogenesisCardiac developmentDosage-sensitive regulatorRING ubiquitin ligasesMulti-subunit complexesTranscriptional regulatory mechanismsUbiquitin E3 ligaseHippo-YAP signaling pathwayHippo-YAP pathwayRegulation of cardiac morphogenesisHeart failureDefective cardiac developmentExpression of genesMammalian heart developmentCardiomyocyte proliferationCell autonomous roleHypoplastic ventricular myocardiumVentricular chamber developmentAdaptor proteinCullin-RINGBiventricular non-compaction
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