2022
DNMT3A R882 Mutations Confer Unique Clinicopathologic Features in MDS Including a High Risk of AML Transformation
Jawad M, Afkhami M, Ding Y, Zhang X, Li P, Young K, Xu ML, Cui W, Zhao Y, Halene S, Al-Kali A, Viswanatha D, Chen D, He R, Zheng G. DNMT3A R882 Mutations Confer Unique Clinicopathologic Features in MDS Including a High Risk of AML Transformation. Frontiers In Oncology 2022, 12: 849376. PMID: 35296003, PMCID: PMC8918526, DOI: 10.3389/fonc.2022.849376.Peer-Reviewed Original ResearchWorse progression-free survivalProgression-free survivalMyelodysplastic syndromeAML transformationMyeloid neoplasmsMDS casesHigh riskR882 mutationsClonal hematopoiesisIndependent risk factorUnique clinicopathologic featuresTertiary medical institutionsDifferent treatment approachesUnique clinicopathologicExcess blastsSevere leukopeniaClinicopathologic featuresMutant patientsRisk factorsLarge cohortTherapeutic implicationsTreatment approachesClinical implicationsClinical-genomic databaseNeoplasms
2018
Distinctive features of gastrointestinal stromal tumors arising from the colon and rectum
Zhu R, Liu F, Grisotti G, Pérez-Irizarry J, Cha CH, Johnson CH, Boffa DJ, Han D, Johung KL, Zhang Y, Khan SA. Distinctive features of gastrointestinal stromal tumors arising from the colon and rectum. Journal Of Gastrointestinal Oncology 2018, 9: 231-240. PMID: 29755761, PMCID: PMC5934147, DOI: 10.21037/jgo.2017.11.12.Peer-Reviewed Original ResearchRectal gastrointestinal stromal tumorGastric gastrointestinal stromal tumorsGastrointestinal stromal tumorsNational Cancer Data BaseAdjuvant therapyOverall survivalSystemic therapyStromal tumorsCases of GISTColonic gastrointestinal stromal tumorsSmall bowel originAdjuvant systemic therapyWorse overall survivalUnique clinicopathologic featuresBowel originTherapy prolongsClinical characteristicsPatient demographicsLocal excisionPrognostic factorsPropensity matchingSurgical treatmentTreatment guidelinesClinicopathologic featuresClinical care
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