2013
Mechanical Properties of Doubly Stabilized Microtubule Filaments
Hawkins T, Sept D, Mogessie B, Straube A, Ross J. Mechanical Properties of Doubly Stabilized Microtubule Filaments. Biophysical Journal 2013, 104: 1517-1528. PMID: 23561528, PMCID: PMC3617445, DOI: 10.1016/j.bpj.2013.02.026.Peer-Reviewed Original ResearchConceptsMicrotubule-stabilizing factorsChemotherapeutic drug taxolMicrotubule-associated proteinsRigidity of microtubulesPresence of taxolProperties of microtubulesNucleotide stateGuanosine-5'-O-(3-thiotriphosphateMechanical properties of microtubulesCytoskeletal filamentsDrug taxolMicrotubulesIntracellular organismsTubulin dimersTreated cellsCell typesCell morphologyMicrotubule mechanicsTaxolAnticancer agentsCellsGuanosine-5NucleotideBinding of drugsMAP4
2008
XMAP215 Is a Processive Microtubule Polymerase
Brouhard GJ, Stear JH, Noetzel TL, Al-Bassam J, Kinoshita K, Harrison SC, Howard J, Hyman AA. XMAP215 Is a Processive Microtubule Polymerase. Cell 2008, 132: 79-88. PMID: 18191222, PMCID: PMC2311386, DOI: 10.1016/j.cell.2007.11.043.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesBiological AssayCatalytic DomainCell DifferentiationCell EnlargementCell LineCytoskeletonDiffusionDimerizationFetal ProteinsForminsGreen Fluorescent ProteinsMicrofilament ProteinsMicroscopy, FluorescenceMicrotubule-Associated ProteinsMicrotubulesNuclear ProteinsPolymersProtein BindingProtein Structure, TertiaryProtein TransportSpodopteraSus scrofaTubulinXenopus laevisXenopus ProteinsConceptsFamily of proteinsSingle-molecule assaysActin polymerasesMicrotubule cytoskeletonProcessive polymeraseTubulin subunit additionDynamic microtubulesMicrotubule polymeraseMicrotubule growthCytoskeletal polymersXMAP215Plus endsMicrotubule latticePolymeraseSubunit additionCell proliferationFree tubulinTubulin dimersMicrotubulesCommon mechanismFast growthTip trackingGrowthCytoskeletonRapid assembly
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