2016
EB1 regulates attachment of Ska1 with microtubules by forming extended structures on the microtubule lattice
Thomas G, Bandopadhyay K, Sutradhar S, Renjith M, Singh P, Gireesh K, Simon S, Badarudeen B, Gupta H, Banerjee M, Paul R, Mitra J, Manna T. EB1 regulates attachment of Ska1 with microtubules by forming extended structures on the microtubule lattice. Nature Communications 2016, 7: 11665. PMID: 27225956, PMCID: PMC4894954, DOI: 10.1038/ncomms11665.Peer-Reviewed Original ResearchConceptsMicrotubule attachmentMicrotubule plus-end tracking protein EB1Plus-end tracking protein EB1Dynamic microtubulesMitotic chromosome alignmentMicrotubule latticeVertebrate cellsProtein complexesChromosome movementChromosome alignmentProtein EB1Biochemical experimentsEB1K-fibersDepletion resultsMicrotubulesVertebratesStructural studiesExtended structureSKA1EukaryotesKinetochoresImportant roleMitosisProtein
2008
XMAP215 Is a Processive Microtubule Polymerase
Brouhard GJ, Stear JH, Noetzel TL, Al-Bassam J, Kinoshita K, Harrison SC, Howard J, Hyman AA. XMAP215 Is a Processive Microtubule Polymerase. Cell 2008, 132: 79-88. PMID: 18191222, PMCID: PMC2311386, DOI: 10.1016/j.cell.2007.11.043.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesBiological AssayCatalytic DomainCell DifferentiationCell EnlargementCell LineCytoskeletonDiffusionDimerizationFetal ProteinsForminsGreen Fluorescent ProteinsMicrofilament ProteinsMicroscopy, FluorescenceMicrotubule-Associated ProteinsMicrotubulesNuclear ProteinsPolymersProtein BindingProtein Structure, TertiaryProtein TransportSpodopteraSus scrofaTubulinXenopus laevisXenopus ProteinsConceptsFamily of proteinsSingle-molecule assaysActin polymerasesMicrotubule cytoskeletonProcessive polymeraseTubulin subunit additionDynamic microtubulesMicrotubule polymeraseMicrotubule growthCytoskeletal polymersXMAP215Plus endsMicrotubule latticePolymeraseSubunit additionCell proliferationFree tubulinTubulin dimersMicrotubulesCommon mechanismFast growthTip trackingGrowthCytoskeletonRapid assembly
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