2018
Treatment Outcomes of Brazilian Inmates with Treponema pallidum and Human Immunodeficiency Virus Infection: A Prospective Cohort Study.
Bet G, Souza G, Croda J, Correa M, de Sales R, Santos R, Viebrantz Enne Sgarbi R, Yassuda R, Coimbra Motta-Castro A, Pompílio M, Simionatto S. Treatment Outcomes of Brazilian Inmates with Treponema pallidum and Human Immunodeficiency Virus Infection: A Prospective Cohort Study. American Journal Of Tropical Medicine And Hygiene 2018, 98: 1603-1608. PMID: 29737273, PMCID: PMC6086195, DOI: 10.4269/ajtmh.17-0592.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusHIV-1 viral loadProspective cohort studyPoor treatment outcomesTreatment outcomesCohort studyHIV infectionViral loadHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionCopies/mLMedical record dataPublic health programsSyphilis treatmentImmunodeficiency virusAcquired syphilisRisk factorsSerological testingVirus infectionBlood samplesMultivariate analysisHealth programsNew casesInfectionTreponema pallidum
2013
MyD88 Deficiency Markedly Worsens Tissue Inflammation and Bacterial Clearance in Mice Infected with Treponema pallidum, the Agent of Syphilis
Silver AC, Dunne DW, Zeiss CJ, Bockenstedt LK, Radolf JD, Salazar JC, Fikrig E. MyD88 Deficiency Markedly Worsens Tissue Inflammation and Bacterial Clearance in Mice Infected with Treponema pallidum, the Agent of Syphilis. PLOS ONE 2013, 8: e71388. PMID: 23940747, PMCID: PMC3734110, DOI: 10.1371/journal.pone.0071388.Peer-Reviewed Original ResearchConceptsMyD88-deficient miceTreponema pallidumMyD88-deficient animalsResistance of miceToll-like receptorsWild-type miceMyD88-deficient macrophagesMacrophage-mediated clearanceHigh pathogen burdenMyD88 deficiencySpirochete Treponema pallidumWT miceTissue infiltratesBacterial clearanceExtensive inflammationTissue inflammationPlasma cellsControl animalsWT macrophagesMost TLRsAnimal modelsMixed mononuclearPathogen burdenMiceT. pallidum
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