Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy
You Y, Tian Y, Yang Z, Shi J, Kwak K, Tong Y, Estania A, Cao J, Hsu W, Liu Y, Chiang C, Schrank B, Huntoon K, Lee D, Li Z, Zhao Y, Zhang H, Gallup T, Ha J, Dong S, Li X, Wang Y, Lu W, Bahrani E, Lee L, Teng L, Jiang W, Lan F, Kim B, Lee A. Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy. Nature Biomedical Engineering 2023, 7: 887-900. PMID: 36635419, DOI: 10.1038/s41551-022-00989-w.Peer-Reviewed Original ResearchConceptsExtracellular vesiclesTranslation of genetic materialFunctional proteinsGenetic materialIntradermal deliveryRNA therapeuticsPhotoaged skinHuman dermal fibroblastsType I collagenMessenger RNA therapeuticsProtein replacement therapyTreatment of photoaged skinCOL1A1 mRNAVesiclesMRNADermal fibroblastsTissues of miceEncapsulated mRNAReduced wrinkle formationProteinTherapyDelivery systemReplacement of collagenMicroneedle arraysCollagen
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