2025
MHC Class II Sharing Appears to Promote Intestinal Allograft Tolerance Through Linked Suppression in a Large Animal Model
Gunes M, Patwardhan S, Merl S, Yang K, Jones R, Chen B, Manell E, Hong J, Jordache P, Atta H, Chauhan I, Almesallmy A, Shamim A, Agwuncha O, Mulder H, Dasari A, Hajosi D, Hawley R, Nowak G, Pereira M, Ko H, Ekanayake-Alper D, Martinez M, Sachs D, Kato T, Yamada K, Sykes M, Weiner J. MHC Class II Sharing Appears to Promote Intestinal Allograft Tolerance Through Linked Suppression in a Large Animal Model. Transplantation 2025, 109: 1506-1519. PMID: 40838866, PMCID: PMC12353661, DOI: 10.1097/tp.0000000000005420.Peer-Reviewed Original ResearchMajor histocompatibility complexAntigen-presenting cells in vivoDonor regulatory T cellsInduction of transplantation toleranceMixed lymphocyte reaction assayClass II matchingTreg-mediated toleranceDonor-specific hyporesponsivenessRegulatory T cellsClinically relevant modelEvidence of toleranceClass II allelesCells in vivoAllograft toleranceTransplantation toleranceGraft toleranceT cellsIntestinal transplantationAntigen-SpecificII allelesIn vitro analysisAnimal modelsClinical protocolsHistocompatibility complexReaction assay
2024
Durable mixed chimerism may permit subsequent immunosuppression-free intestinal transplantation—A proof-of-principle study
Patwardhan S, Gunes M, Manell E, Hong J, Jordache P, Chauhan I, Almesallmy A, Mulder H, Ekanayake-Alper D, Hajosi D, Ko H, Shanmugarajah K, Cetrulo C, Nowak G, Sachs D, Sykes M, Weiner J. Durable mixed chimerism may permit subsequent immunosuppression-free intestinal transplantation—A proof-of-principle study. American Journal Of Transplantation 2024, 25: 825-835. PMID: 39442670, DOI: 10.1016/j.ajt.2024.10.014.Peer-Reviewed Original ResearchConceptsHematopoietic stem cell transplantationTransplantation toleranceDoses of immunosuppressive medicationsGraft-versus-host diseaseHematopoietic stem cell transplantation donorsMixed lymphocyte reaction assayGraft-versus-hostStem cell transplantationLong-term immunosuppressionSolid organ transplantationHistological signs of rejectionAssociated with higher ratesSigns of rejectionImmunosuppressive therapyNonmyeloablative conditioningHaplotype mismatchCell transplantationImmune toleranceDefinitive treatmentImmunosuppressive medicationsIntestinal failureMHC-matchedIntestinal allograftsProof-of-principle studyIntestinal transplantation
2011
Learning to live together: harnessing regulatory T cells to induce organ transplant tolerance.
Chang A, Bhattacharya N. Learning to live together: harnessing regulatory T cells to induce organ transplant tolerance. The Yale Journal Of Biology And Medicine 2011, 84: 345-51. PMID: 22180672, PMCID: PMC3238321.Peer-Reviewed Original Research
2009
A CD8 T cell–intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo
Fehr T, Lucas CL, Kurtz J, Onoe T, Zhao G, Hogan T, Vallot C, Rao A, Sykes M. A CD8 T cell–intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo. Blood 2009, 115: 1280-1287. PMID: 20007805, PMCID: PMC2826238, DOI: 10.1182/blood-2009-07-230680.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalApoptosis Regulatory ProteinsBone Marrow TransplantationCalcineurinCD4-Positive T-LymphocytesCD40 LigandCD8-Positive T-LymphocytesCyclosporineFemaleFlow CytometryGraft SurvivalImmune ToleranceMiceMice, Inbred C57BLMice, TransgenicNFATC Transcription FactorsReceptors, Antigen, T-CellSignal TransductionThymectomyTransplantation ChimeraConceptsCD8 T cellsCalcineurin/NFAT pathwayTolerance inductionCD8 toleranceT cell receptorCD4 cellsT cellsAllogeneic bone marrow transplantation modelNFAT pathwayT cell-intrinsic roleAnti-CD154 antibodyFailure of CD8Adoptive transfer studiesBone marrow transplantation modelBone marrow transplantationCell-intrinsic roleCalcineurin-NFAT pathwayCD8 cellsRegulatory cellsTransplantation toleranceMarrow transplantationTransplantation modelAnergy inductionNFAT1 deficiencyNuclear factor
2007
Regulatory Transplantation Tolerance and “Stemness”: Evidence That Foxp3 May Play a Regulatory Role in SOCS-3 Gene Transcription
Muthukumarana P, Chae WJ, Maher S, Rosengard BR, Bothwell AL, Metcalfe SM. Regulatory Transplantation Tolerance and “Stemness”: Evidence That Foxp3 May Play a Regulatory Role in SOCS-3 Gene Transcription. Transplantation 2007, 84: s6-s11. PMID: 17632414, DOI: 10.1097/01.tp.0000269116.06510.db.Peer-Reviewed Original ResearchConceptsExpression of Foxp3Wt-Foxp3Regulatory transplantation toleranceSOCS-3Immune effector cellsStem cell-related factorsHuman T cell lineCell-related factorsT cell linesJurkat human T cell lineSOCS-3 transcriptsLIF transcriptionSuppressor of cytokineTransplantation toleranceEffector cellsT lymphocytesFoxp3Inhibitory factorKey mediatorT cell signal transductionAxotrophinTregsFurther evidenceTranscriptional activityRegulatory role
1998
Techniques of Skin, Renal, and Vascular Transplantation in the Rat
Darr U, Tellides G. Techniques of Skin, Renal, and Vascular Transplantation in the Rat. 1998, 73-81. DOI: 10.1007/978-3-642-72140-3_10.Peer-Reviewed Original ResearchSkin graftsAllograft rejectionImmune responseCell-mediated allograft rejectionAllograft immune responseRat renal transplantationClinical organ transplantationFree skin graftExperimental animal modelsOrgan transplantation modelsTechnique of skinAortic transplantationKidney transplantationRenal transplantationOrgan allograftsTransplant arteriosclerosisTransplantation toleranceTransplantation immunologyTransplantation modelOrgan transplantationAnimal modelsMicrosurgical techniquesTransplantationGraft modelRat kidney
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