Durable mixed chimerism may permit subsequent immunosuppression-free intestinal transplantation—A proof-of-principle study
Patwardhan S, Gunes M, Manell E, Hong J, Jordache P, Chauhan I, Almesallmy A, Mulder H, Ekanayake-Alper D, Hajosi D, Ko H, Shanmugarajah K, Cetrulo C, Nowak G, Sachs D, Sykes M, Weiner J. Durable mixed chimerism may permit subsequent immunosuppression-free intestinal transplantation—A proof-of-principle study. American Journal Of Transplantation 2024, 25: 825-835. PMID: 39442670, DOI: 10.1016/j.ajt.2024.10.014.Peer-Reviewed Original ResearchConceptsHematopoietic stem cell transplantationTransplantation toleranceDoses of immunosuppressive medicationsGraft-versus-host diseaseHematopoietic stem cell transplantation donorsMixed lymphocyte reaction assayGraft-versus-hostStem cell transplantationLong-term immunosuppressionSolid organ transplantationHistological signs of rejectionAssociated with higher ratesSigns of rejectionImmunosuppressive therapyNonmyeloablative conditioningHaplotype mismatchCell transplantationImmune toleranceDefinitive treatmentImmunosuppressive medicationsIntestinal failureMHC-matchedIntestinal allograftsProof-of-principle studyIntestinal transplantation
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