2023
PI3K Pathway Alterations in Peritoneal Metastases are Associated with Earlier Recurrence in Patients with Colorectal Cancer Undergoing Optimal Cytoreductive Surgery
Peerenboom R, Dhiman A, Witmer H, Spurr L, Polite B, Eng O, Shergill A, Turaga K. PI3K Pathway Alterations in Peritoneal Metastases are Associated with Earlier Recurrence in Patients with Colorectal Cancer Undergoing Optimal Cytoreductive Surgery. Annals Of Surgical Oncology 2023, 30: 3114-3122. PMID: 36637640, DOI: 10.1245/s10434-022-12784-7.Peer-Reviewed Original ResearchConceptsOptimal cytoreductive surgeryPI3K pathway alterationsRecurrence-free survivalAssociated with early recurrenceCytoreductive surgeryCRC-PMPeritoneal metastasisRTK-RASEarly recurrenceImpact of tumor biologyReduced risk of recurrenceCRC-PM patientsMonths to recurrenceBiologically heterogeneous diseaseRisk of recurrenceCox proportional hazards modelsRTK-RAS pathwayClinically meaningful impactPI3KFrequency of alterationsSignaling pathwayProportional hazards modelCytoreduced patientsOptimal cytoreductionConclusionsIn patients
2018
Evaluating the cost of surveillance for non-muscle-invasive bladder cancer: an analysis based on risk categories
Mossanen M, Wang Y, Szymaniak J, Tan W, Huynh M, Preston M, Trinh Q, Sonpavde G, Kibel A, Chang S. Evaluating the cost of surveillance for non-muscle-invasive bladder cancer: an analysis based on risk categories. World Journal Of Urology 2018, 37: 2059-2065. PMID: 30446799, DOI: 10.1007/s00345-018-2550-x.Peer-Reviewed Original ResearchConceptsBladder cancerProgression to muscle-invasive diseaseNon-muscle-invasive bladder cancerHigh-risk disease patientsEORTC risk calculatorHigh-risk NMIBCManagement of NMIBCMuscle-invasive diseaseLow-risk tumorsBiologically heterogeneous diseaseHigh-risk diseaseSurveillance of patientsMethodsA Markov modelLong-term surveillanceHigh-risk groupPatient risk groupsOverall cost of careCost of surveillanceCost of careIntermediate-riskSurveillance cystoscopyExpensive malignanciesIndex patientPatient basisNMIBC
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