PI3K Pathway Alterations in Peritoneal Metastases are Associated with Earlier Recurrence in Patients with Colorectal Cancer Undergoing Optimal Cytoreductive Surgery
Peerenboom R, Dhiman A, Witmer H, Spurr L, Polite B, Eng O, Shergill A, Turaga K. PI3K Pathway Alterations in Peritoneal Metastases are Associated with Earlier Recurrence in Patients with Colorectal Cancer Undergoing Optimal Cytoreductive Surgery. Annals Of Surgical Oncology 2023, 30: 3114-3122. PMID: 36637640, DOI: 10.1245/s10434-022-12784-7.Peer-Reviewed Original ResearchConceptsOptimal cytoreductive surgeryPI3K pathway alterationsRecurrence-free survivalAssociated with early recurrenceCytoreductive surgeryCRC-PMPeritoneal metastasisRTK-RASEarly recurrenceImpact of tumor biologyReduced risk of recurrenceCRC-PM patientsMonths to recurrenceBiologically heterogeneous diseaseRisk of recurrenceCox proportional hazards modelsRTK-RAS pathwayClinically meaningful impactPI3KFrequency of alterationsSignaling pathwayProportional hazards modelCytoreduced patientsOptimal cytoreductionConclusionsIn patients
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