2004
Metformin therapy increases insulin-like growth factor binding protein-1 in hyperinsulinemic women with polycystic ovary syndrome
Pawelczyk L, Spaczynski RZ, Banaszewska B, Duleba AJ. Metformin therapy increases insulin-like growth factor binding protein-1 in hyperinsulinemic women with polycystic ovary syndrome. European Journal Of Obstetrics & Gynecology And Reproductive Biology 2004, 113: 209-213. PMID: 15063962, DOI: 10.1016/j.ejogrb.2003.09.031.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeQuantitative insulin sensitivity check indexInsulin-like growth factorMetformin therapyBody mass indexIGFBP-1Ovary syndromeHyperinsulinemic womenSerum levelsFree insulin-like growth factorTotal IGF-I levelsGlucose/insulin ratioInsulin sensitivity check indexGrowth factorHyperandrogenic PCOS womenIGFBP-1 concentrationsIGFBP-1 levelsFree testosterone indexIGF-I levelsEnd of therapyProtein 1PCOS womenTestosterone indexCompensatory hyperinsulinemiaMass index
1992
Diverse effects of insulin-like growth factor I on glucose, lipid, and amino acid metabolism
Boulware SD, Tamborlane WV, Matthews LS, Sherwin RS. Diverse effects of insulin-like growth factor I on glucose, lipid, and amino acid metabolism. American Journal Of Physiology 1992, 262: e130-e133. PMID: 1733244, DOI: 10.1152/ajpendo.1992.262.1.e130.Peer-Reviewed Original ResearchConceptsInsulin-like growth factor IIGF-I levelsGrowth factor IInsulin secretionTotal IGF-I levelsFree IGF-I levelsAcid metabolismRecombinant human insulin-like growth factor IFactor IAmino acid metabolismFree fatty acid metabolismHealthy nonobese subjectsHuman insulin-like growth factor IHepatic glucose productionBranched-chain amino acidsExogenous glucose infusionFatty acid metabolismGlucagon levelsInsulin levelsNonobese subjectsContinuous infusionConcomitant inhibitory effectTwo- to threefold increaseC-peptideGlucose infusion
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