2021
Structural analyses of an RNA stability element interacting with poly(A)
Torabi SF, Chen YL, Zhang K, Wang J, DeGregorio SJ, Vaidya AT, Su Z, Pabit SA, Chiu W, Pollack L, Steitz JA. Structural analyses of an RNA stability element interacting with poly(A). Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2026656118. PMID: 33785601, PMCID: PMC8040590, DOI: 10.1073/pnas.2026656118.Peer-Reviewed Original ResearchConceptsRNA stability elementCis-acting RNA elementsGlobal conformational changesRich internal loopCryo-electron microscopyRice transposable elementsDiverse genomesDouble-helical regionsSmall-angle X-ray scatteringEne motifTransposable elementsGlobal structural changesRNA interactionsRNA stabilityBioinformatics studiesRNA elementsStability elementShort helixConformational changesDecay pathwaysInternal loopBiochemical structureTriplex structureBindingMotif
2018
APOBEC as an Endogenous Mutagen in Cancers of the Head and Neck
Sasaki T, Issaeva N, Yarbrough W, Anderson K. APOBEC as an Endogenous Mutagen in Cancers of the Head and Neck. Current Cancer Research 2018, 275-292. DOI: 10.1007/978-3-319-78762-6_10.Peer-Reviewed Original ResearchDiverse physiological processesFamily of cytidineApolipoprotein B mRNA-editing enzyme catalytic polypeptideEnzyme catalytic polypeptideU conversionBioinformatics studiesEndogenous mutagensAPOBEC3 functionGenomic DNAPhysiological processesCatalytic polypeptideEditing mechanismBioinformatics dataAPOBEC activityHuman cancersTarget nucleotidesProduction of neoantigensAPOBEC3 proteinsDiverse cancersSquamous cell carcinomaHuman papillomavirus expressionTherapeutic avenuesProteinStructural evidenceDNA
2014
A new paradigm for transcription factor TFIIB functionality
Gelev V, Zabolotny JM, Lange M, Hiromura M, Yoo SW, Orlando JS, Kushnir A, Horikoshi N, Paquet E, Bachvarov D, Schaffer PA, Usheva A. A new paradigm for transcription factor TFIIB functionality. Scientific Reports 2014, 4: 3664. PMID: 24441171, PMCID: PMC3895905, DOI: 10.1038/srep03664.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationAnimalsBinding SitesCell CycleCell LineDatasets as TopicGene ExpressionGene Expression ProfilingGene Expression RegulationGene Expression Regulation, ViralGene Knockdown TechniquesGene SilencingGenes, LethalGenome, HumanHerpesvirus 1, HumanHumansOrgan SpecificityProtein BindingRNA Polymerase IITranscription Factor TFIIBTranscription Initiation SiteTranscription, GeneticTranscriptomeConceptsTranscription initiationGene expressionGeneral transcription factor TFIIBTranscription factor TFIIBRNA polymerase IIGlobal gene expressionHuman gene expressionPolymerase IIGene transcriptionBioinformatics analysisBioinformatics studiesGene promoterHuman promotersCellular functionalityMitotic chromatidsTFIIBCell linesTranscriptionPromoterExpression
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