2025
Non-disruptive matrix turnover is a conserved feature of biofilm aggregate growth in paradigm pathogenic species
Reichhardt C, Matwichuk M, Lewerke L, Jacobs H, Yan J, Parsek M. Non-disruptive matrix turnover is a conserved feature of biofilm aggregate growth in paradigm pathogenic species. MBio 2025, 16: e03935-24. PMID: 39982068, PMCID: PMC11898600, DOI: 10.1128/mbio.03935-24.Peer-Reviewed Original ResearchConceptsSynthesize EPSBiofilm aggregatesBiofilm matrixBiofilm matrix exopolysaccharidesBiofilm-forming speciesBiofilm matrix compositionStudy of biofilmsMatrix exopolysaccharidesVibrio cholerae</i>.Cellular biomassPathogenic speciesModel organismsBacterial speciesExtracellular DNAExopolysaccharideBiofilm stabilityMulticellular aggregatesCell-free matricesBiofilmCell-free formSpeciesMatrix turnoverAggregate peripheryBacteriaMatrix components
2021
Morphogenesis and cell ordering in confined bacterial biofilms
Zhang Q, Li J, Nijjer J, Lu H, Kothari M, Alert R, Cohen T, Yan J. Morphogenesis and cell ordering in confined bacterial biofilms. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2107107118. PMID: 34330824, PMCID: PMC8346881, DOI: 10.1073/pnas.2107107118.Peer-Reviewed Original ResearchConceptsInherent developmental programsBiofilm-dwelling cellsBiofilm-forming speciesSingle-cell imagingDevelopmental programSpecific matrix componentsCell orderingBiofilm developmentSpherical biofilmsBacterial cellsCell communityExtracellular matrixBiofilm morphologyBacterial biofilmsBiophysical mechanismsMatrix componentsHost tissuesBiofilmsBiofilm growthStiff gelsCellsMorphogenesisMutagenesisSpeciesVibrio
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