2005
56 ATTENUATION OF RODENT LUNG ISCHEMIA/REPERFUSION INJURY BY SPHINGOSINE 1-PHOSPHATE
Moreno-Vinasco L, Bonde P, Jacobson J, Garcia J. 56 ATTENUATION OF RODENT LUNG ISCHEMIA/REPERFUSION INJURY BY SPHINGOSINE 1-PHOSPHATE. Journal Of Investigative Medicine 2005, 53: s366. DOI: 10.2310/6650.2005.00206.55.Peer-Reviewed Original ResearchIschemia/reperfusion injuryR injuryMyeloperoxidase activityLung transplantationReperfusion injuryVascular permeabilityAlbumin concentrationLung ischemia/reperfusion injuryLung tissue myeloperoxidase activityBronchoalveolar lavage cell countsLavage cell countsLung preservation techniquesPulmonary artery ligationR lung injuryTissue myeloperoxidase activityTime of reperfusionPeriod of reperfusionLung vascular permeabilityPotential therapeutic roleSprague-Dawley ratsImproved patient outcomesNovel therapeutic interventionsProfound clinical implicationsAlveolar damageDonor lungs
2001
PR-39 and PR-11 peptides inhibit ischemia-reperfusion injury by blocking proteasome-mediated IκBα degradation
Bao J, Sato K, Li M, Gao Y, Abid R, Aird W, Simons M, Post M. PR-39 and PR-11 peptides inhibit ischemia-reperfusion injury by blocking proteasome-mediated IκBα degradation. AJP Heart And Circulatory Physiology 2001, 281: h2612-h2618. PMID: 11709430, DOI: 10.1152/ajpheart.2001.281.6.h2612.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesCells, CulturedCysteine EndopeptidasesDNA-Binding ProteinsEndothelium, VascularHumansI-kappa B ProteinsIntercellular Adhesion Molecule-1MaleMultienzyme ComplexesMyocardial Reperfusion InjuryMyocardiumNADPH OxidasesNeutrophilsNF-KappaB Inhibitor alphaPeptide FragmentsPeroxidasePhosphoproteinsProteasome Endopeptidase ComplexRatsRats, Sprague-DawleyReactive Oxygen SpeciesUmbilical VeinsVascular Cell Adhesion Molecule-1Ventricular Function, LeftConceptsIschemia-reperfusion injuryB alpha degradationAdhesion molecule-1PR-11Alpha degradationNeutrophil infiltrationMyeloperoxidase activityInfarct sizeMolecule-1Vascular cell adhesion molecule-1Myocardial ischemia-reperfusion injuryIntercellular adhesion molecule-1Cell adhesion molecule-1Ventricular systolic pressureTime of reperfusionIschemia-reperfusion modelMin of ischemiaPR-39Controls 24 hBlood pressureSystolic pressureCardiac functionIntramyocardial injectionIκBα degradationAdhesion molecules
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