2006
Effects of Simvastatin and Oral Contraceptive Agent on Polycystic Ovary Syndrome: Prospective, Randomized, Crossover Trial
Banaszewska B, Pawelczyk L, Spaczynski RZ, Dziura J, Duleba AJ. Effects of Simvastatin and Oral Contraceptive Agent on Polycystic Ovary Syndrome: Prospective, Randomized, Crossover Trial. The Journal Of Clinical Endocrinology & Metabolism 2006, 92: 456-461. PMID: 17105841, DOI: 10.1210/jc.2006-1988.Peer-Reviewed Original ResearchConceptsOral contraceptive pillsPolycystic ovary syndromeLow-density lipoprotein cholesterolTotal testosteroneLipoprotein cholesterolOvary syndromeSystemic inflammationCrossover trialSoluble vascular cell adhesion molecule-1Treatment of PCOSVascular cell adhesion molecule-1Ovarian theca-interstitial cellsCell adhesion molecule-1Oral contraceptive agentsSerum total testosteronePrimary outcome measureC-reactive proteinEffect of simvastatinTheca-interstitial cellsAdhesion molecule-1Academic medical centerRandom-effects modelCardiovascular riskFree testosteroneTotal cholesterol
2004
Mevastatin inhibits ovarian theca–interstitial cell proliferation and steroidogenesis
Izquierdo D, Foyouzi N, Kwintkiewicz J, Duleba AJ. Mevastatin inhibits ovarian theca–interstitial cell proliferation and steroidogenesis. Fertility And Sterility 2004, 82: 1193-1197. PMID: 15474095, DOI: 10.1016/j.fertnstert.2004.03.037.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeTheca-interstitial cellsCardiovascular riskCultured theca-interstitial cellsVascular smooth muscle proliferationSmooth muscle proliferationPotential therapeutic agentConcentration-dependent inhibitionDiphenyl tetrazolium bromide (MTT) assayConcentration-dependent decreaseDNA synthesisMesenchymal hyperplasiaOvary syndromeTetrazolium bromide assayMuscle proliferationMAIN OUTCOMECulture protein contentSpecific radioimmunoassayEffects of mevastatinT productionTherapeutic agentsMTT proliferationBromide assayDimethylthiazol-2Cell proliferationProliferation of ovarian theca‐interstitial cells is modulated by antioxidants and oxidative stress
Duleba AJ, Foyouzi N, Karaca M, Pehlivan T, Kwintkiewicz J, Behrman HR. Proliferation of ovarian theca‐interstitial cells is modulated by antioxidants and oxidative stress. Human Reproduction 2004, 19: 1519-1524. PMID: 15178657, DOI: 10.1093/humrep/deh299.Peer-Reviewed Original ResearchConceptsOxidative stressOvarian theca-interstitial cellsModest oxidative stressPathological conditionsPolycystic ovary syndromeI cellsTheca-interstitial cellsDose-dependent decreaseThecal-interstitial cellsXanthine oxidaseExcessive oxidative stressVitamin E succinateDepletion of antioxidantsMesenchymal hyperplasiaOvarian homeostasisOvary syndromeRat TGreater oxidative stressBiphasic effectIU/Inhibited proliferationSerum-free mediumThymidine incorporationReactive oxygen speciesOvarian mesenchyme
1999
Tumor Necrosis Factor-α Stimulates Proliferation of Rat Ovarian Theca-Interstitial Cells1
Spaczynski R, Arici A, Duleba A. Tumor Necrosis Factor-α Stimulates Proliferation of Rat Ovarian Theca-Interstitial Cells1. Biology Of Reproduction 1999, 61: 993-998. PMID: 10491635, DOI: 10.1095/biolreprod61.4.993.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeTNF-alphaTheca-interstitial cellsOvarian theca-interstitial cellsRat Ovarian Theca-Interstitial CellsInsulin-like growth factor ISerum TNF-alphaGrowth factor II cell proliferationDose-dependent fashionCytometry DNA analysisEffect of insulinOvary syndromeOvarian functionRat TTumor necrosisPathophysiologic roleTotal cell countProliferative indexCell countPotent modulatorFactor IIncorporation assayIGFInsulinProliferation and Differentiation of Rat Theca-Interstitial Cells: Comparison of Effects Induced by Platelet-Derived Growth Factor and Insulin-Like Growth Factor-I1
Duleba A, Spaczynski R, Arici A, Carbone R, Behrman H. Proliferation and Differentiation of Rat Theca-Interstitial Cells: Comparison of Effects Induced by Platelet-Derived Growth Factor and Insulin-Like Growth Factor-I1. Biology Of Reproduction 1999, 60: 546-550. PMID: 10026097, DOI: 10.1095/biolreprod60.3.546.Peer-Reviewed Original ResearchConceptsPlatelet-derived growth factorInsulin-like growth factorTheca-interstitial cellsGrowth factorRat theca-interstitial cellsImmature Sprague-Dawley ratsI cellsSprague-Dawley ratsDose-dependent increaseDNA synthesisComparison of effectsActive cellsIGFFlow cytometryThymidine incorporationStimulatory effectProliferationCell countingCytometryCellsDehydrogenase activityTotal numberIndividual subpopulationsProportionDividing cells
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