Insights into distinct signaling profiles of the µOR activated by diverse agonists
Qu Q, Huang W, Aydin D, Paggi J, Seven A, Wang H, Chakraborty S, Che T, DiBerto J, Robertson M, Inoue A, Suomivuori C, Roth B, Majumdar S, Dror R, Kobilka B, Skiniotis G. Insights into distinct signaling profiles of the µOR activated by diverse agonists. Nature Chemical Biology 2022, 19: 423-430. PMID: 36411392, PMCID: PMC11098091, DOI: 10.1038/s41589-022-01208-y.Peer-Reviewed Original ResearchConceptsRespiratory depressionCryo-EM structureMitragynine pseudoindoxylM-opioid receptorSignaling outcomesB-arrestinMolecular dynamics simulationsFatal respiratory depressionCryo-EMG-proteinBinding sitesMOR agonistsEffective analgesicSafety profileEfficacy profileSubtype activationAnimal studiesDynamics simulationsOrthosteric pocketLofentanilIntracellular sidePlant-derivedAgonistsDiverse agonistsActive-state conformation
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