2024
Exploring the Impact of Age, Frailty, and Multimorbidity on the Effect of ICU Interventions: A Systematic Review of Randomized Controlled Trials
Perrella A, Geen O, Ahuja M, Scott S, Kaushik R, Ferrante L, Brummel N, Muscedere J, Rochwerg B. Exploring the Impact of Age, Frailty, and Multimorbidity on the Effect of ICU Interventions: A Systematic Review of Randomized Controlled Trials. Critical Care Medicine 2024, 52: e463-e472. PMID: 38661459, PMCID: PMC11974607, DOI: 10.1097/ccm.0000000000006315.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCritical care interventionsRandomized Controlled TrialsCare interventionsOlder adultsCluster Randomized Controlled TrialStatistically significant effect modificationSubgroup effectsIll Older AdultsControlled TrialsCritically ill older adultsSystematic review of randomized controlled trialsSignificant effect modificationReview of randomized controlled trialsCritical care randomized controlled trialsCritical care journalsStatistically significant subgroup effectsIndividual patient preferencesSubgroups of ageIntervention effectsMultimorbidityEffect modificationFrailty subgroupsICU interventionsStudy characteristicsGeneral medicine
2019
What is the effect of a decision aid in potentially vulnerable parents? Insights from the head CT choice randomized trial
Skains RM, Kuppermann N, Homme JL, Kharbanda AB, Tzimenatos L, Louie JP, Cohen DM, Nigrovic LE, Westphal JJ, Shah ND, Inselman J, Ferrara MJ, Herrin J, Montori VM, Hess EP. What is the effect of a decision aid in potentially vulnerable parents? Insights from the head CT choice randomized trial. Health Expectations 2019, 23: 63-74. PMID: 31758633, PMCID: PMC6978876, DOI: 10.1111/hex.12965.Peer-Reviewed Original ResearchConceptsLow health literacyPhysician trustNon-white parentsHealth literacyDecisional conflictImportant traumatic brain injuryTraumatic brain injuryDecision aidLess decisional conflictDisadvantaged parentsGreater increaseUsual careIntermediate riskVulnerable parentsBrain injuryHigher numeracySecondary analysisSubgroup effectsArm assignmentPatient dyadsSocioeconomic statusTrialsRegression modelsParent characteristicsParents
2017
Effectiveness of a Decision Aid in Potentially Vulnerable Patients: A Secondary Analysis of the Chest Pain Choice Multicenter Randomized Trial
Rising K, Hollander J, Schaffer J, Kline J, Torres C, Diercks D, Jones R, Owen K, Meisel Z, Demers M, Leblanc A, Shah N, Inselman J, Herrin J, Montori V, Hess E. Effectiveness of a Decision Aid in Potentially Vulnerable Patients: A Secondary Analysis of the Chest Pain Choice Multicenter Randomized Trial. Medical Decision Making 2017, 38: 69-78. PMID: 28525723, DOI: 10.1177/0272989x17706363.Peer-Reviewed Original ResearchConceptsUsual careHealth literacySecondary analysisAcute coronary syndromeDecision aidOne-thirdChest painCoronary syndromePatient characteristicsSDM interventionsIntervention groupVulnerable patientsHigh school educationPatientsControl groupPhysician trustPatient trustSubgroup effectsArm assignmentVulnerable subgroupsSociodemographic groupsMulticenterTrialsSimilar extentPhysicians
2006
Chemoprevention of Second Cancers
Mayne ST, Cartmel B. Chemoprevention of Second Cancers. Cancer Epidemiology Biomarkers & Prevention 2006, 15: 2033-2037. PMID: 17057027, DOI: 10.1158/1055-9965.epi-06-0415.Peer-Reviewed Original ResearchConceptsSecond cancersSubgroup effectsTobacco-related cancersColorectal adenomatous polypsObservational epidemiologic studiesPrimary cancerSmoking statusTumor characteristicsFuture trialsCancer sitesLifestyle habitsChemopreventive efficacyBreast cancerSecondary cancersAdenomatous polypsEpidemiologic studiesChemopreventive agentsAlcohol consumptionSkin cancerNutritional statusChemopreventionCancerGenetic susceptibilityCancer treatmentTrial results
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