2021
iRGD‐Liposomes Enhance Tumor Delivery and Therapeutic Efficacy of Antisense Oligonucleotide Drugs against Primary Prostate Cancer and Bone Metastasis
Guan J, Guo H, Tang T, Wang Y, Wei Y, Seth P, Li Y, Dehm S, Ruoslahti E, Pang H. iRGD‐Liposomes Enhance Tumor Delivery and Therapeutic Efficacy of Antisense Oligonucleotide Drugs against Primary Prostate Cancer and Bone Metastasis. Advanced Functional Materials 2021, 31 PMID: 34211360, PMCID: PMC8240484, DOI: 10.1002/adfm.202100478.Peer-Reviewed Original ResearchAndrogen receptorProstate cancerSubcutaneous xenograftsSolid tumorsAR splice variantsHigh loading efficiencySignificant side effectsProstate cancer treatmentPrimary prostate cancerBone metastasesAR expressionLoading efficiencyEfficient knockdownTumor deliverySide effectsProstate tumorsTherapeutic efficacyTumor growthTreatment studiesTumor tissueAntisense oligonucleotide drugXenograftsAntitumor efficacyCancer treatmentMetastasis
2020
HDAC inhibition synergizes with ALK inhibitors to overcome resistance in a novel ALK mutated lung adenocarcinoma model
Stockhammer P, Ho CSL, Hegedus L, Lotz G, Molnár E, Bankfalvi A, Herold T, Kalbourtzis S, Ploenes T, Eberhardt WEE, Schuler M, Aigner C, Schramm A, Hegedus B. HDAC inhibition synergizes with ALK inhibitors to overcome resistance in a novel ALK mutated lung adenocarcinoma model. Lung Cancer 2020, 144: 20-29. PMID: 32353632, DOI: 10.1016/j.lungcan.2020.04.002.Peer-Reviewed Original ResearchConceptsALK tyrosine kinase inhibitorsCell linesALK fusion oncogeneDistinct resistance mutationsTreatment-naïve ALKMalignant pleural effusionPost-treatment tumorsLung cancer modelPan-HDAC inhibitorsNovel therapeutic approachesTyrosine kinase inhibitorsMesenchymal transition (EMT) markersLung adenocarcinoma modelTime of resistancePleural effusionALK inhibitionLung adenocarcinomaSubcutaneous xenograftsALK inhibitorsTherapeutic approachesCell line pairsCancer modelAdenocarcinoma modelHDAC inhibitionTransition markers
2004
Inhibition of the EGFR and hedgehog signaling pathways demonstrate potent growth inhibition in an animal model of esophageal carcinogenesis
Sui G, Bonde P, Dhara S, Marti G, Freguson M, Wang J, Jaffee E, Duncan M, Montgomery E, Maitra A, Harmon J. Inhibition of the EGFR and hedgehog signaling pathways demonstrate potent growth inhibition in an animal model of esophageal carcinogenesis. Journal Of Surgical Research 2004, 121: 278-279. DOI: 10.1016/j.jss.2004.07.040.Peer-Reviewed Original ResearchEpidermal growth factor receptorSignificant growth inhibitionEsophageal carcinogenesisCell linesVivo growthGrowth inhibitionSquamous cell carcinomaSprague-Dawley ratsReliable preclinical modelsHh pathway antagonistsImportant oncogenic pathwaysBilious refluxMock-treated cellsGrowth factor receptorAdenosquamous cancerCell carcinomaEsophageal cancerSD ratsPreclinical modelsSubcutaneous xenograftsAthymic miceSmall molecule inhibitorsAnimal modelsPotent growth inhibitionExperimental therapeutics
1996
Targeting microtubule-associated proteins in glioblastoma: A new strategy for selective therapy
Piepmeier J, Pedersen P, Yoshida D, Greer C. Targeting microtubule-associated proteins in glioblastoma: A new strategy for selective therapy. Annals Of Surgical Oncology 1996, 3: 543-549. PMID: 8915486, DOI: 10.1007/bf02306087.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic Agents, AlkylatingBrain NeoplasmsCarrier ProteinsCell LineColony-Forming Units AssayEstramustineFlow CytometryGlioblastomaHumansImmunohistochemistryMiceMice, NudeMicrotubule-Associated ProteinsNeoplasm TransplantationRadiation-Sensitizing AgentsThymidineTransplantation, HeterologousTumor Cells, CulturedConceptsSubcutaneous xenograftsGlioblastoma cellsHuman glioblastoma cellsMicrotubule-associated proteinsHuman glioblastomaPotent antimitotic effectsUse of estramustineAntimicrotubule agentsEstramustine-binding proteinPreclinical dataEstramustineNeoplastic cellsAntiproliferative effectsSelective therapyGlioma cellsAntimitotic effectCytotoxic effectsGlioblastomaUseful targetTherapyXenograftsLaboratory investigationsSelective effectAntimitotic activityCells
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