2023
Age-associated disparity in phagocytic clearance affects the efficacy of cancer nanotherapeutics
Wang Y, Deng W, Lee D, Yan L, Lu Y, Dong S, Huntoon K, Antony A, Li X, Ye R, Zhao Y, Zhao F, Schrank B, Ha J, Kang M, Yang M, Gong P, Lorenzi P, Tan L, Gallup T, Tang S, Yang Z, Li J, Sanford N, Wang H, Kim B, Jiang W. Age-associated disparity in phagocytic clearance affects the efficacy of cancer nanotherapeutics. Nature Nanotechnology 2023, 19: 255-263. PMID: 37723279, DOI: 10.1038/s41565-023-01502-3.Peer-Reviewed Original ResearchConceptsCancer nanotherapeuticsCancer nanomedicineScavenger receptor MARCOPhagocytic clearanceUptake of nanoparticlesAntitumour responseTumor deliveryTherapeutic blockadeAntitumour efficacyAge-Associated DecreaseHepatic phagocytesAntitumour effectsYoung miceHepatic macrophagesAged miceTreatment outcomesTreat multiple human diseasesProtein level analysisHepatic uptakeAge-related declineNon-human primatesNanotherapeuticsMiceNanomedicinePhagocytic uptake
2021
iRGD‐Liposomes Enhance Tumor Delivery and Therapeutic Efficacy of Antisense Oligonucleotide Drugs against Primary Prostate Cancer and Bone Metastasis
Guan J, Guo H, Tang T, Wang Y, Wei Y, Seth P, Li Y, Dehm S, Ruoslahti E, Pang H. iRGD‐Liposomes Enhance Tumor Delivery and Therapeutic Efficacy of Antisense Oligonucleotide Drugs against Primary Prostate Cancer and Bone Metastasis. Advanced Functional Materials 2021, 31 PMID: 34211360, PMCID: PMC8240484, DOI: 10.1002/adfm.202100478.Peer-Reviewed Original ResearchAndrogen receptorProstate cancerSubcutaneous xenograftsSolid tumorsAR splice variantsHigh loading efficiencySignificant side effectsProstate cancer treatmentPrimary prostate cancerBone metastasesAR expressionLoading efficiencyEfficient knockdownTumor deliverySide effectsProstate tumorsTherapeutic efficacyTumor growthTreatment studiesTumor tissueAntisense oligonucleotide drugXenograftsAntitumor efficacyCancer treatmentMetastasis
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