Monitoring T-Cell Activation in the Tumor Microenvironment by PET Imaging of the Chemokine CXCL9.
Jacobson O, Zhang H, Olkowski C, Ghaemi B, Basuli F, Shi J, Bell M, Parween F, Ganesan S, Esparza T, Escorcia F, Choyke P, Farber J. Monitoring T-Cell Activation in the Tumor Microenvironment by PET Imaging of the Chemokine CXCL9. Journal Of Nuclear Medicine 2025, 66: 1372-1377. PMID: 40813232, PMCID: PMC12410298, DOI: 10.2967/jnumed.125.269795.Peer-Reviewed Original ResearchConceptsC-X-C motif chemokine ligand 9T cell activationT cell-engaging therapiesHumanized mouse modelT cellsTumor microenvironmentIFN-gXenograft modelGroup 1 innate lymphoid cellsEfficacy of cancer immunotherapyEngaging therapiesMethods:</b>Biomarkers of immune activationTumor-to-background ratioResults:</b>PET imagingResponse to immunotherapyTumor-to-backgroundImmune-mediated diseasesMonitoring of immune responsesSubcutaneous xenograft modelChemokine ligand 9Monitoring T-cell activationNoninvasive visualizationNoninvasive monitoring
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